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    hpo hippo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37247, updated on 30-Nov-2017
    Official Symbol
    hpoprovided by FlyBase
    Official Full Name
    hippoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261456
    Locus tag
    Dmel_CG11228
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11228; Dmel\CG11228; dMST; hipo; Hippo; Hpo; MST; MST2
    Location:
    56D13-56D13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19493996..19496856, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15381501..15384361, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene CG8201 gene product from transcript CG8201-RV Neighboring gene tubulin-binding cofactor B Neighboring gene Outer segment 6 Neighboring gene Rab escort protein Neighboring gene CG15120 gene product from transcript CG15120-RA Neighboring gene CG16926 gene product from transcript CG16926-RB Neighboring gene CG11007 gene product from transcript CG11007-RB

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    • Apoptosis - fly, conserved biosystem (from KEGG)
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    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transducer, downstream of receptor, with serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    R8 cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    border follicle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hippo signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    morphogenesis of an epithelial sheet IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of organ growth TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organ growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-threonine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of protein processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to ionizing radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction by protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress-activated protein kinase signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    CG11228 gene product from transcript CG11228-RB
    Names
    CG11228-PA
    CG11228-PB
    MST
    hippo
    hippo kinase
    hpo-PA
    hpo-PB
    NP_001261092.1
    NP_611427.1

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      19493996..19496856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274163.1NP_001261092.1  hippo, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261092.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0S6
      UniProtKB/TrEMBL
      A0A0B4KFW0
      Related
      FBpp0304253.1, FBtr0331920
      Conserved Domains (3) summary
      cd06612
      Location:38293
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      smart00220
      Location:42293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam11629
      Location:608655
      Mst1_SARAH; C terminal SARAH domain of Mst1
    2. NM_137583.5NP_611427.1  hippo, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611427.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8T0S6
      UniProtKB/TrEMBL
      A0A0B4KFW0
      Related
      FBpp0085688.1, FBtr0086500
      Conserved Domains (3) summary
      cd06612
      Location:38293
      STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
      smart00220
      Location:42293
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam11629
      Location:608655
      Mst1_SARAH; C terminal SARAH domain of Mst1
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