Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    RPS6KA3 ribosomal protein S6 kinase A3 [ Homo sapiens (human) ]

    Gene ID: 6197, updated on 15-Oct-2017
    Official Symbol
    RPS6KA3provided by HGNC
    Official Full Name
    ribosomal protein S6 kinase A3provided by HGNC
    Primary source
    HGNC:HGNC:10432
    See related
    Ensembl:ENSG00000177189 MIM:300075; Vega:OTTHUMG00000021231
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
    Summary
    This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    Xp22.12
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (20149911..20267514, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20168029..20285523, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9-like Neighboring gene eukaryotic translation initiation factor 1A, X-linked Neighboring gene RNA, 7SK small nuclear pseudogene 183 Neighboring gene uncharacterized LOC105373146 Neighboring gene RNA, U6 small nuclear 133, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Coffin-Lowry syndrome
    MedGen: C0265252 OMIM: 303600 GeneReviews: Coffin-Lowry Syndrome
    Compare labs
    Mental retardation, X-linked 19
    MedGen: C0796225 OMIM: 300844 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2012-08-09)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2012-08-09)

    ClinGen Genome Curation PagePubMed

    Replication interactions

    Interaction Pubs
    Knockdown of ribosomal protein S6 kinase, polypeptide 3 (RPS6KA3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat RSK2 is selectively involved in LTR stimulation by the HIV-1 Tat protein, but constitutively active RSK2 is unable to stimulate the LTR PubMed
    tat Interaction of HIV-1 Tat with p90 ribosomal S6 kinase 2 (RSK2) is observed in vivo and in vitro. The critical interacting residues lie within amino acids 36-39 in Tat and 1-360 in RSK2. RSK2 supports HIV-1 Tat transactivation via binding to F38 PubMed
    tat Activation of the N-terminal RSK2 kinase activity is enhanced by HIV-1 Tat in a dose-dependent manner. PubMed
    tat Phosphorylation of serine 227 in RSK2 is increased by Tat; mutation at position F38 abolishes the Tat-mediated phosphorylation of RSK2. PubMed

    Go to the HIV-1, Human Interaction Database

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
      Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
    • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
      Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • CREB phosphorylation, organism-specific biosystem (from REACTOME)
      CREB phosphorylation, organism-specific biosystemNerve growth factor (NGF) activates multiple signalling pathways that mediate the phosphorylation of CREB at the critical regulatory site, serine 133. CREB phosphorylation at serine 133 is a crucial ...
    • CREB phosphorylation through the activation of Ras, organism-specific biosystem (from REACTOME)
      CREB phosphorylation through the activation of Ras, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Cellular Senescence, organism-specific biosystem (from REACTOME)
      Cellular Senescence, organism-specific biosystemCellular senescence involves irreversible growth arrest accompanied by phenotypic changes such as enlarged morphology, reorganization of chromatin through formation of senescence-associated heterochr...
    • Cellular responses to stress, organism-specific biosystem (from REACTOME)
      Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
    • Coregulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
      Coregulation of Androgen receptor activity, organism-specific biosystem
      Coregulation of Androgen receptor activity
    • Cytoplasmic Ribosomal Proteins, organism-specific biosystem (from WikiPathways)
      Cytoplasmic Ribosomal Proteins, organism-specific biosystemThe contents of this pathway represents the ribosomal proteins involved in translation.
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • ERK/MAPK targets, organism-specific biosystem (from REACTOME)
      ERK/MAPK targets, organism-specific biosystemERK/MAPK kinases have a number of targets within the nucleus, usually transcription factors or other kinases. The best known targets, ELK1, ETS1, ATF2, MITF, MAPKAPK2, MSK1, RSK1/2/3 and MEF2 are ann...
    • ErbB1 downstream signaling, organism-specific biosystem (from Pathway Interaction Database)
      ErbB1 downstream signaling, organism-specific biosystem
      ErbB1 downstream signaling
    • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
      Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Insulin resistance, organism-specific biosystem (from KEGG)
      Insulin resistance, organism-specific biosystemInsulin resistance is a condition where cells become resistant to the effects of insulin. It is often found in people with health disorders, including obesity, type 2 diabetes mellitus, non-alcoholic...
    • Kit receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Kit receptor signaling pathway, organism-specific biosystemKit is a cytokine receptor that belongs to the type III receptor tyrosine kinase family. It is structurally similar to platelet-derived growth factor recpetors (PDGFRs), colony stimulating factor-1 r...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MAP kinase activation in TLR cascade, organism-specific biosystem (from REACTOME)
      MAP kinase activation in TLR cascade, organism-specific biosystemThe mitogen activated protein kinase (MAPK) cascade, one of the most ancient and evolutionarily conserved signaling pathways, is involved in many processes of immune responses. The MAP kinases cascad...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystem (from REACTOME)
      MAPK targets/ Nuclear events mediated by MAP kinases, organism-specific biosystemMAPKs are protein kinases that, once activated, phosphorylate their specific cytosolic or nuclear substrates at serine and/or threonine residues. Such phosphorylation events can either positively or ...
    • MyD88 cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88 cascade initiated on plasma membrane, organism-specific biosystemMammalian myeloid differentiation factor 88 (MyD88) is Toll/interleukin (IL)-1 (TIR)-domain containing adapter protein which plays crucial role in TLR signaling. All TLRs, with only one exception of...
    • MyD88 dependent cascade initiated on endosome, organism-specific biosystem (from REACTOME)
      MyD88 dependent cascade initiated on endosome, organism-specific biosystemUpon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I ...
    • MyD88-independent TLR3/TLR4 cascade, organism-specific biosystem (from REACTOME)
      MyD88-independent TLR3/TLR4 cascade, organism-specific biosystemMyD88-independent signaling pathway is shared by TLR3 and TLR4 cascades. TIR-domain-containing adapter-inducing interferon-beta (TRIF or TICAM1) is a key adapter molecule in transducing signals from ...
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
      NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Nuclear Events (kinase and transcription factor activation), organism-specific biosystem (from REACTOME)
      Nuclear Events (kinase and transcription factor activation), organism-specific biosystemAn important function of the kinase cascade triggered by neurotrophins is to induce the phosphorylation and activation of transcription factors in the nucleus to initiate new programs of gene express...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Post NMDA receptor activation events, organism-specific biosystem (from REACTOME)
      Post NMDA receptor activation events, organism-specific biosystemCa2+ influx through the NMDA receptor initiates subsequent molecular pathways that have a defined role in establishing long-lasting synaptic changes. The molecular signaling initiated by a rise in Ca...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • RSK activation, organism-specific biosystem (from REACTOME)
      RSK activation, organism-specific biosystemRibosomal S6 kinase has four isoforms in humans and each of the isoforms have sic conserved phosphorylation sites (S221, S363, S380,S749, T359,T573) out of which four are important for its activity (...
    • Recycling pathway of L1, organism-specific biosystem (from REACTOME)
      Recycling pathway of L1, organism-specific biosystemL1 functions in many aspects of neuronal development including axon outgrowth and neuronal migration. These functions require coordination between L1 and the actin cytoskeleton. F-actin continuously ...
    • Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystem (from REACTOME)
      Senescence-Associated Secretory Phenotype (SASP), organism-specific biosystemThe culture medium of senescent cells in enriched in secreted proteins when compared with the culture medium of quiescent i.e. presenescent cells and these secreted proteins constitute the so-called ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Signalling by NGF, organism-specific biosystem (from REACTOME)
      Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
    • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystem (from REACTOME)
      TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation, organism-specific biosystemTRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
    • TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
      TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemTRIF(TICAM1) was shown to induce IRF3/7 and NF-?B activation and apoptosis through distinct intracellular signaling pathways [Han KJ et al 2004; Kaiser WJ and Offermann MK et al 2005]. TRIF consists...
    • Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 10 (TLR10) Cascade, organism-specific biosystemLittle is known about TLR10 ligands. It has been established that the receptor homodimerizes upon binding and signals in an MyD88-dependent manner (Hasan U et al 2005; Nyman T et al 2008). It may als...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemToll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and in...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 5 (TLR5) Cascade, organism-specific biosystemTLR5 is the receptor for flagellin, the protein that forms bacterial flagella. Unlike most other Pathogen-Associated Molecular Patterns (PAMPs), flagellin does not undergo any posttranslational modif...
    • Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 7/8 (TLR7/8) Cascade, organism-specific biosystemRNA can serve as a danger signal, both in its double-stranded form (that is associated with viral infection), as well as single-stranded RNA (ssRNA). Specifically, guanosine (G)- and uridine (U)-rich...
    • Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 9 (TLR9) Cascade, organism-specific biosystemCpG DNA is an unusual Pathogen-Associated Molecular Pattern (PAMP). Cytosine methylation exists in mammalian but not bacterial cells, and most (but not all) CpG in the mammalian genome is methylated....
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
      Toll-Like Receptors Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • mTOR signaling pathway, organism-specific biosystem (from KEGG)
      mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    • mTOR signaling pathway, conserved biosystem (from KEGG)
      mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    kinase activity TAS
    Traceable Author Statement
    more info
     
    magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of cell growth TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of DNA-templated transcription in response to stress TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of translation in response to stress TAS
    Traceable Author Statement
    more info
    PubMed 
    response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    skeletal system development TAS
    Traceable Author Statement
    more info
    PubMed 
    toll-like receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    ribosomal protein S6 kinase alpha-3
    Names
    MAP kinase-activated protein kinase 1b
    MAPK-activated protein kinase 1b
    MAPKAP kinase 1b
    MAPKAPK-1b
    RSK-2
    S6K-alpha-3
    insulin-stimulated protein kinase 1
    p90-RSK 3
    ribosomal S6 kinase 2
    ribosomal protein S6 kinase, 90kDa, polypeptide 3
    NP_004577.1
    XP_005274630.1
    XP_005274634.1
    XP_006724570.1
    XP_011543857.1
    XP_011543858.1
    XP_011543859.1
    XP_011543860.1
    XP_011543861.1
    XP_011543862.1
    XP_011543863.1
    XP_011543864.1
    XP_011543865.1
    XP_016885202.1
    XP_016885203.1
    XP_016885204.1
    XP_016885205.1
    XP_016885206.1
    XP_016885207.1
    XP_016885208.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007488.1 RefSeqGene

      Range
      5001..121722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004586.2NP_004577.1  ribosomal protein S6 kinase alpha-3

      See identical proteins and their annotated locations for NP_004577.1

      Status: REVIEWED

      Source sequence(s)
      AA317826, AA858312, AB102662, AK022869, AL732366, AV684171, BC015451, BQ427696, BU618685, CA843287, CA843526, CK905714, U08316, W00439
      Consensus CDS
      CCDS14197.1
      UniProtKB/Swiss-Prot
      P51812
      Related
      ENSP00000368884.3, OTTHUMP00000023036, ENST00000379565.7, OTTHUMT00000056011
      Conserved Domains (2) summary
      cd05582
      Location:72388
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:402740
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      20149911..20267514 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029716.1XP_016885205.1  ribosomal protein S6 kinase alpha-3 isoform X6

      UniProtKB/TrEMBL
      B7ZB17
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    2. XM_017029715.1XP_016885204.1  ribosomal protein S6 kinase alpha-3 isoform X6

      UniProtKB/TrEMBL
      B7ZB17
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    3. XM_011545559.1XP_011543861.1  ribosomal protein S6 kinase alpha-3 isoform X4

      See identical proteins and their annotated locations for XP_011543861.1

      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    4. XM_017029713.1XP_016885202.1  ribosomal protein S6 kinase alpha-3 isoform X6

      UniProtKB/TrEMBL
      B7ZB17
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    5. XM_006724507.3XP_006724570.1  ribosomal protein S6 kinase alpha-3 isoform X8

      See identical proteins and their annotated locations for XP_006724570.1

      UniProtKB/TrEMBL
      B4DG22
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374711
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    6. XM_017029719.1XP_016885208.1  ribosomal protein S6 kinase alpha-3 isoform X8

      UniProtKB/TrEMBL
      B4DG22
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374711
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    7. XM_017029717.1XP_016885206.1  ribosomal protein S6 kinase alpha-3 isoform X6

      UniProtKB/TrEMBL
      B7ZB17
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    8. XM_011545561.1XP_011543863.1  ribosomal protein S6 kinase alpha-3 isoform X4

      See identical proteins and their annotated locations for XP_011543863.1

      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    9. XM_005274573.2XP_005274630.1  ribosomal protein S6 kinase alpha-3 isoform X3

      See identical proteins and their annotated locations for XP_005274630.1

      Conserved Domains (4) summary
      smart00220
      Location:68327
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:72388
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:402739
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:421678
      Pkinase; Protein kinase domain
    10. XM_011545556.1XP_011543858.1  ribosomal protein S6 kinase alpha-3 isoform X2

      Conserved Domains (4) summary
      smart00220
      Location:68333
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:72394
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:408745
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:427684
      Pkinase; Protein kinase domain
    11. XM_011545555.1XP_011543857.1  ribosomal protein S6 kinase alpha-3 isoform X1

      Conserved Domains (4) summary
      smart00220
      Location:68333
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:72394
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:408737
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:428685
      Pkinase; Protein kinase domain
    12. XM_011545560.1XP_011543862.1  ribosomal protein S6 kinase alpha-3 isoform X4

      See identical proteins and their annotated locations for XP_011543862.1

      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    13. XM_011545557.2XP_011543859.1  ribosomal protein S6 kinase alpha-3 isoform X4

      See identical proteins and their annotated locations for XP_011543859.1

      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    14. XM_011545558.2XP_011543860.1  ribosomal protein S6 kinase alpha-3 isoform X4

      See identical proteins and their annotated locations for XP_011543860.1

      Conserved Domains (4) summary
      smart00220
      Location:40305
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:44366
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:380718
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:400657
      Pkinase; Protein kinase domain
    15. XM_011545563.2XP_011543865.1  ribosomal protein S6 kinase alpha-3 isoform X6

      See identical proteins and their annotated locations for XP_011543865.1

      UniProtKB/TrEMBL
      B7ZB17
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    16. XM_017029714.1XP_016885203.1  ribosomal protein S6 kinase alpha-3 isoform X6

      UniProtKB/TrEMBL
      B7ZB17
      Conserved Domains (2) summary
      cd05582
      Location:44360
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:374712
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    17. XM_005274577.2XP_005274634.1  ribosomal protein S6 kinase alpha-3 isoform X9

      See identical proteins and their annotated locations for XP_005274634.1

      Conserved Domains (4) summary
      smart00220
      Location:39298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:43359
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:373710
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:392649
      Pkinase; Protein kinase domain
    18. XM_017029718.1XP_016885207.1  ribosomal protein S6 kinase alpha-3 isoform X7

      Conserved Domains (4) summary
      smart00220
      Location:39298
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:43359
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:373711
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:393650
      Pkinase; Protein kinase domain
    19. XM_011545562.1XP_011543864.1  ribosomal protein S6 kinase alpha-3 isoform X5

      Conserved Domains (4) summary
      smart00220
      Location:39304
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05582
      Location:43365
      STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
      cd14176
      Location:379717
      STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
      pfam00069
      Location:399656
      Pkinase; Protein kinase domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      20198431..20315161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center