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    TK1 thymidine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 7083, updated on 26-Nov-2016
    Official Symbol
    TK1provided by HGNC
    Official Full Name
    thymidine kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:11830
    See related
    Ensembl:ENSG00000167900 HPRD:01771; MIM:188300; Vega:OTTHUMG00000150674
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TK2
    Summary
    The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]
    Orthologs
    Location:
    17q25.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (78174079..78187208, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (76170160..76183285, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 99 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 2 Neighboring gene uncharacterized LOC107985050 Neighboring gene synaptogyrin 2 Neighboring gene arylformamidase Neighboring gene baculoviral IAP repeat containing 5 Neighboring gene transmembrane protein 235

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    nucleoside kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    thymidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    DNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    deoxyribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotetramerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    pyrimidine nucleoside salvage TAS
    Traceable Author Statement
    more info
     
    thymidine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    thymidine kinase, cytosolic
    Names
    thymidine kinase 1 soluble isoform
    NP_003249.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051962.1 RefSeqGene

      Range
      5001..18126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001346663.1NP_001333592.1  thymidine kinase, cytosolic isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC021593, AC087645
    2. NM_003258.4NP_003249.3  thymidine kinase, cytosolic isoform 1

      See identical proteins and their annotated locations for NP_003249.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA633286, BC006484, BI754079
      Consensus CDS
      CCDS11754.1
      UniProtKB/Swiss-Prot
      P04183
      Related
      ENSP00000301634, OTTHUMP00000198229, ENST00000301634, OTTHUMT00000319577
      Conserved Domains (1) summary
      cl23762
      Location:18192
      TK; Thymidine kinase

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      78174079..78187208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024992.1XP_016880481.1  

      Related
      ENSP00000468425, OTTHUMP00000256722, ENST00000588734, OTTHUMT00000437051

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      76234697..76247823 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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