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    Tbx3 T-box 3 [ Mus musculus (house mouse) ]

    Gene ID: 21386, updated on 8-Apr-2018
    Official Symbol
    Tbx3provided by MGI
    Official Full Name
    T-box 3provided by MGI
    Primary source
    MGI:MGI:98495
    See related
    Ensembl:ENSMUSG00000018604 Vega:OTTMUSG00000029655
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Ertd189e
    Expression
    Biased expression in adrenal adult (RPKM 118.3), small intestine adult (RPKM 47.5) and 8 other tissues See more
    Orthologs
    Location:
    5 F; 5 60.34 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (119670319..119684724)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120120678..120134610)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene T-box 3, opposite strand 1 Neighboring gene predicted gene 16063 Neighboring gene predicted gene 16064 Neighboring gene T-box 3, opposite strand 2 Neighboring gene predicted gene, 42017

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
    • Signaling pathways regulating pluripotency of stem cells, organism-specific biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, organism-specific biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    • Signaling pathways regulating pluripotency of stem cells, conserved biosystem (from KEGG)
      Signaling pathways regulating pluripotency of stem cells, conserved biosystemPluripotent stem cells (PSCs) are basic cells with an indefinite self-renewal capacity and the potential to generate all the cell types of the three germinal layers. The types of PSCs known to date i...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    animal organ morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    anterior/posterior axis specification, embryo ISO
    Inferred from Sequence Orthology
    more info
     
    atrioventricular bundle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in mammary gland duct morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac muscle cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell aging IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell aging ISO
    Inferred from Sequence Orthology
    more info
     
    cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digit morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic heart tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female genitalia development ISO
    Inferred from Sequence Orthology
    more info
     
    follicle-stimulating hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    forelimb morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limbic system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    luteinizing hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    male genitalia development ISO
    Inferred from Sequence Orthology
    more info
     
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    mammary placode formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mammary placode formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mesoderm morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of myoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    roof of mouth development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    sinoatrial node cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    specification of animal organ position IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Preferred Names
    T-box transcription factor TBX3
    Names
    T-box protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011535.3NP_035665.2  T-box transcription factor TBX3 isoform 1

      See identical proteins and their annotated locations for NP_035665.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA543734, AK052453, AK145436, BB054411, BB694449, BB728182, CJ216213
      Consensus CDS
      CCDS19613.1
      UniProtKB/Swiss-Prot
      P70324
      UniProtKB/TrEMBL
      Q3ULL3
      Related
      ENSMUSP00000018748.8, OTTMUSP00000038109, ENSMUST00000018748.8, OTTMUST00000073569
      Conserved Domains (2) summary
      pfam12598
      Location:323411
      TBX; T-box transcription factor
      cd00182
      Location:102307
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    2. NM_198052.2NP_932169.1  T-box transcription factor TBX3 isoform 2

      See identical proteins and their annotated locations for NP_932169.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AA543734, BB054411, BB694449, BB728182, BC096551, CJ216213
      Consensus CDS
      CCDS19614.1
      UniProtKB/TrEMBL
      Q4VA43
      Related
      ENSMUSP00000112519.1, OTTMUSP00000038110, ENSMUST00000121021.7, OTTMUST00000073570
      Conserved Domains (2) summary
      pfam12598
      Location:303391
      TBX; T-box transcription factor
      cd00182
      Location:102287
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      119670319..119684724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530276.3XP_006530339.1  T-box transcription factor TBX3 isoform X1

      See identical proteins and their annotated locations for XP_006530339.1

      UniProtKB/Swiss-Prot
      P70324
      Conserved Domains (2) summary
      pfam12598
      Location:323411
      TBX; T-box transcription factor
      cd00182
      Location:102307
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
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