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    rest RE1-silencing transcription factor [ Danio rerio (zebrafish) ]

    Gene ID: 564772, updated on 26-Oct-2017
    Official Symbol
    restprovided by ZNC
    Official Full Name
    RE1-silencing transcription factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080415-1
    See related
    Ensembl:ENSDARG00000103046 Vega:OTTDARG00000028191
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
    Also known as
    NRSF
    Orthologs
    Location:
    chromosome: 14
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (52421488..52433320, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (51705068..51717595, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide B Neighboring gene nitric oxide associated 1 Neighboring gene DP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1, like Neighboring gene exosome component 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    branchiomotor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    facial nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    facial nucleus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    facial nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    motor neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of neuron maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron maturation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    smoothened signaling pathway involved in dorsal/ventral neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    RE1-silencing transcription factor
    Names
    RE-1 silencer of transcription
    neural-restrictive silencer factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001353866.1NP_001340795.1  RE1-silencing transcription factor

      Status: VALIDATED

      Source sequence(s)
      AL954718
      Conserved Domains (5) summary
      sd00017
      Location:266286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:326343
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam10243
      Location:453769
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12756
      Location:293367
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:306327
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      52421488..52433320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001922872.6XP_001922907.1  RE1-silencing transcription factor

      UniProtKB/TrEMBL
      A0A0R4IKA2
      Related
      ENSDARP00000136293.1, OTTDARP00000030688
      Conserved Domains (5) summary
      sd00017
      Location:266286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:326343
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam10243
      Location:453769
      MIP-T3; Microtubule-binding protein MIP-T3
      pfam12756
      Location:293367
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:306327
      zf-H2C2_2; Zinc-finger double domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001039820.1: Suppressed sequence

      Description
      NM_001039820.1: This RefSeq was temporarily suppressed because the CDS was partial.
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