Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    NDI1 NADH-ubiquinone reductase (H(+)-translocating) NDI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854919, updated on 3-Sep-2017
    Gene symbol
    NDI1
    Gene description
    NADH-ubiquinone reductase (H(+)-translocating) NDI1
    Primary source
    SGD:S000004589
    Locus tag
    YML120C
    Gene type
    protein coding
    RNA name
    NADH-ubiquinone reductase (H(+)-translocating) NDI1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See NDI1 in Map Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (28266..29807, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Rag GTPase GTR1 Neighboring gene hypothetical protein Neighboring gene 3'-5' poly(A) RNA exonuclease

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • NAD/NADP-NADH/NADPH mitochondrial interconversion, organism-specific biosystem (from BIOCYC)
      NAD/NADP-NADH/NADPH mitochondrial interconversion, organism-specific biosystem:NAD and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than any other...
    • NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast), conserved biosystem (from BIOCYC)
      NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast), conserved biosystem|FRAME:NAD| and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than an...
    • aerobic respiration (cytochrome c), organism-specific biosystem (from BIOCYC)
      aerobic respiration (cytochrome c), organism-specific biosystem:NADH and :FADH2 are formed in the glycolytic and TCA cycles. Each of these energy-rich molecules has a pair of electrons with high transfer potential. The transfer of the electrons is performed by a...
    • aerobic respiration (linear view), organism-specific biosystem (from BIOCYC)
      aerobic respiration (linear view), organism-specific biosystemThe electron transport chain is the final step of the respiratory pathway, carried out by several large multisubunit enzyme complexes embedded in the mitochondrial inner membrane. The net effect of...
    • aerobic respiration II (cytochrome c) (yeast), conserved biosystem (from BIOCYC)
      aerobic respiration II (cytochrome c) (yeast), conserved biosystemGeneral Background Like |FRAME: Fermentation fermentation|, respiration is a process by which electrons are passed from an electron donor to a terminal electron acceptor. However, in respiration the...
    • superpathway NAD/NADP - NADH/NADPH interconversion, organism-specific biosystem (from BIOCYC)
      superpathway NAD/NADP - NADH/NADPH interconversion, organism-specific biosystem:NAD and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than any other...
    • superpathway NAD/NADP - NADH/NADPH interconversion (yeast), conserved biosystem (from BIOCYC)
      superpathway NAD/NADP - NADH/NADPH interconversion (yeast), conserved biosystem|FRAME:NAD| and its reduced and phosphorylated derivatives are essential metabolites in all organisms and are, except for protons, water and oxygen, integrated with more biochemical reactions than an...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    NADH dehydrogenase (ubiquinone) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    NADH oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chronological cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrial electron transport, NADH to ubiquinone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    NADH-ubiquinone reductase (H(+)-translocating) NDI1
    NP_013586.1
    • NADH:ubiquinone oxidoreductase; transfers electrons from NADH to ubiquinone in respiratory chain but does not pump protons, in contrast to higher eukaryotic multisubunit respiratory complex I; upon apoptotic stress, is activated in mitochondria by N-terminal cleavage, then translocates to cytoplasm to induce apoptosis; homolog of human AIFM2; yeast NDI1 complements several phenotypes of human cell line with mutated MT-ND4, implicated in Leber hereditary optic neuropathy

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      28266..29807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182483.1NP_013586.1  TPA: NADH-ubiquinone reductase (H(+)-translocating) NDI1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013586.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32340
      Conserved Domains (2) summary
      COG1252
      Location:51509
      Ndh; NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]
      cl21454
      Location:258313
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Support Center