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    Irs1 insulin receptor substrate 1 [ Mus musculus (house mouse) ]

    Gene ID: 16367, updated on 24-Sep-2017
    Official Symbol
    Irs1provided by MGI
    Official Full Name
    insulin receptor substrate 1provided by MGI
    Primary source
    MGI:MGI:99454
    See related
    Ensembl:ENSMUSG00000055980 Vega:OTTMUSG00000016464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G972R; IRS-1
    Orthologs
    Location:
    1 C5; 1 42.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (82233105..82291439, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (82229680..82288014, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA pseudogene Neighboring gene microRNA 6344 Neighboring gene rhomboid domain containing 1 Neighboring gene predicted gene, 46095 Neighboring gene collagen, type IV, alpha 4 Neighboring gene collagen, type IV, alpha 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    insulin-like growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol 3-kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane receptor protein tyrosine kinase adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    NOT insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    insulin-like growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of somatostatin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucagon secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import in response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glycogen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mesenchymal cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase B signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    caveola ISO
    Inferred from Sequence Orthology
    more info
     
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    insulin receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    insulin receptor substrate 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010570.4NP_034700.2  insulin receptor substrate 1

      See identical proteins and their annotated locations for NP_034700.2

      Status: VALIDATED

      Source sequence(s)
      AC123690, AC137845
      Consensus CDS
      CCDS15096.1
      UniProtKB/Swiss-Prot
      P35569
      UniProtKB/TrEMBL
      Q543V3
      Related
      ENSMUSP00000063795.2, OTTMUSP00000017705, ENSMUST00000069799.2, OTTMUST00000039671
      Conserved Domains (3) summary
      cd01204
      Location:155258
      PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)
      cd01257
      Location:11118
      PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain
      pfam00169
      Location:17110
      PH; PH domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      82233105..82291439 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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