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    Grn granulin [ Mus musculus (house mouse) ]

    Gene ID: 14824, updated on 8-Nov-2017
    Official Symbol
    Grnprovided by MGI
    Official Full Name
    granulinprovided by MGI
    Primary source
    MGI:MGI:95832
    See related
    Ensembl:ENSMUSG00000034708 Vega:OTTMUSG00000002816
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pgrn; epithelin
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 113.5), ovary adult (RPKM 110.4) and 28 other tissues See more
    Orthologs
    Location:
    11 D; 11 66.29 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (102430322..102436809)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (102291636..102298123)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RUN domain containing 3A Neighboring gene solute carrier family 25, member 39 Neighboring gene microRNA 6930 Neighboring gene family with sequence similarity 171, member A2 Neighboring gene integrin alpha 2b

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    blastocyst hatching IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chondrocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male mating behavior ISO
    Inferred from Sequence Orthology
    more info
     
    neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    granulins
    Names
    PC cell-derived growth factor
    PCDGF
    PEPI
    acrogranulin
    proepithelin
    progranulin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008175.4NP_032201.2  granulins precursor

      See identical proteins and their annotated locations for NP_032201.2

      Status: VALIDATED

      Source sequence(s)
      AK018744, AK152705, AW456643, BY275129
      Consensus CDS
      CCDS48943.1
      UniProtKB/TrEMBL
      Q3U9N4, Q9D2V3
      Related
      ENSMUSP00000046340.4, OTTMUSP00000002716, ENSMUST00000049460.10, OTTMUST00000005699
      Conserved Domains (1) summary
      smart00277
      Location:296346
      GRAN; Granulin

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      102430322..102436809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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