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    GRK6 G protein-coupled receptor kinase 6 [ Homo sapiens (human) ]

    Gene ID: 2870, updated on 6-Aug-2017
    Official Symbol
    GRK6provided by HGNC
    Official Full Name
    G protein-coupled receptor kinase 6provided by HGNC
    Primary source
    HGNC:HGNC:4545
    See related
    Ensembl:ENSG00000198055 MIM:600869; Vega:OTTHUMG00000163401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPRK6
    Summary
    This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q35.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (177426496..177442849)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176853687..176869850)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII Neighboring gene PRR7 antisense RNA 1 Neighboring gene proline rich 7, synaptic Neighboring gene drebrin 1 Neighboring gene PDZ and LIM domain 7

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
    NHGRI GWA Catalog
    New loci associated with kidney function and chronic kidney disease.
    NHGRI GWA Catalog
    Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
    NHGRI GWA Catalog
    • CXCR4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
      CXCR4-mediated signaling events, organism-specific biosystem
      CXCR4-mediated signaling events
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Corticotropin-releasing hormone signaling pathway, organism-specific biosystem (from WikiPathways)
      Corticotropin-releasing hormone signaling pathway, organism-specific biosystemCorticotropin-releasing hormone (CRH) is a neuropeptide secreted abundantly in the paraventricular nucleus of the hypothalamus, amygdala, cerebral cortex and cerebellum in the central nervous system ...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
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    • Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystem (from WikiPathways)
      Follicle Stimulating Hormone (FSH) signaling pathway, organism-specific biosystemThe Follicle Stimulating Hormone (FSH) is an anterior pituitary gonadotropin belonging to the family of glycoprotein hormones that includes thyroid stimulating hormone (TSH), Leutinizing Hormone (LH)...
    • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
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      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
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    • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
      Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
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    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ32135

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    G-protein coupled receptor kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    beta-adrenergic receptor kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-adrenergic receptor kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-adrenergic receptor kinase activity TAS
    Traceable Author Statement
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of G-protein coupled receptor protein signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    G protein-coupled receptor kinase 6
    NP_001004105.1
    NP_001004106.1
    NP_002073.2
    XP_006714921.1
    XP_006714922.1
    XP_011532839.1
    XP_011532840.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031981.1 RefSeqGene

      Range
      5001..21164
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004105.2NP_001004105.1  G protein-coupled receptor kinase 6 isoform C

      See identical proteins and their annotated locations for NP_001004105.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 2, resulting in a shorter isoform (C) with a distinct C-terminus compared to isoform B.
      Source sequence(s)
      AF040752, BC009277, BI258860
      Consensus CDS
      CCDS43406.1
      UniProtKB/Swiss-Prot
      P43250
      Related
      ENSP00000348230.5, OTTHUMP00000223836, ENST00000355958.9, OTTHUMT00000373207
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. NM_001004106.2NP_001004106.1  G protein-coupled receptor kinase 6 isoform A

      See identical proteins and their annotated locations for NP_001004106.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate acceptor splice site in the last exon, compared to variant 2, resulting in a shorter isoform (A) compared to isoform B.
      Source sequence(s)
      AC145098, BC009277, BI258860
      Consensus CDS
      CCDS34303.1
      UniProtKB/Swiss-Prot
      P43250
      Related
      ENSP00000347655.5, OTTHUMP00000223834, ENST00000355472.9, OTTHUMT00000373204
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. NM_002082.3NP_002073.2  G protein-coupled receptor kinase 6 isoform B

      See identical proteins and their annotated locations for NP_002073.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (B).
      Source sequence(s)
      AC145098, AF040751, BC009277, BI258860
      Consensus CDS
      CCDS47348.1
      UniProtKB/Swiss-Prot
      P43250
      Related
      ENSP00000433511.1, OTTHUMP00000231483, ENST00000528793.5, OTTHUMT00000387003
      Conserved Domains (3) summary
      smart00220
      Location:186448
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:185469
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:35179
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      177426496..177442849
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714859.2XP_006714922.1  G protein-coupled receptor kinase 6 isoform X2

      Conserved Domains (3) summary
      smart00220
      Location:154416
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:153437
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:3147
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. XM_011534537.2XP_011532839.1  G protein-coupled receptor kinase 6 isoform X3

      Conserved Domains (3) summary
      smart00220
      Location:147409
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:146430
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:47140
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. XM_006714858.3XP_006714921.1  G protein-coupled receptor kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_006714921.1

      UniProtKB/TrEMBL
      B3KPS5
      Conserved Domains (3) summary
      smart00220
      Location:156418
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05630
      Location:155439
      STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
      cl02565
      Location:20149
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    4. XM_011534538.1XP_011532840.1  G protein-coupled receptor kinase 6 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:1183
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1204
      PKc_like; Protein Kinases, catalytic domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      176287084..176303247
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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