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    Gata1 GATA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 14460, updated on 13-May-2017
    Official Symbol
    Gata1provided by MGI
    Official Full Name
    GATA binding protein 1provided by MGI
    Primary source
    MGI:MGI:95661
    See related
    Ensembl:ENSMUSG00000031162 Vega:OTTMUSG00000018011
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gf-1; eryf1; Gata-1
    Orthologs
    Location:
    X A1.1; X 3.59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (7959260..7976682, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (7536386..7544941, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene histone deacetylase 6 Neighboring gene predicted gene, 39488 Neighboring gene proteasome (prosome, macropain) subunit, beta type 6, pseudogene Neighboring gene glyoxalase domain containing 5 Neighboring gene oxidative stress-responsive serine-rich protein 1 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding, bending IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    RNA polymerase II transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding ISO
    Inferred from Sequence Orthology
    more info
     
    enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    basophil differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to thyroid hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    eosinophil differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    eosinophil fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    megakaryocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    megakaryocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    myeloid cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
     
    platelet formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    platelet formation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of osteoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of definitive erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of definitive erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glycoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of glycoprotein biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of primitive erythrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activation by promoter-enhancer looping IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    erythroid transcription factor
    Names
    GATA-binding factor 1
    NF-E1 DNA-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008089.2NP_032115.1  erythroid transcription factor

      See identical proteins and their annotated locations for NP_032115.1

      Status: VALIDATED

      Source sequence(s)
      AL670169, X15763
      Consensus CDS
      CCDS29981.1
      UniProtKB/Swiss-Prot
      P17679
      Related
      ENSMUSP00000033502.7, OTTMUSP00000019548, ENSMUST00000033502.13, OTTMUST00000043496
      Conserved Domains (2) summary
      smart00401
      Location:202247
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:203249
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      7959260..7976682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247448.2XP_011245750.1  erythroid transcription factor isoform X1

      See identical proteins and their annotated locations for XP_011245750.1

      UniProtKB/Swiss-Prot
      P17679
      Conserved Domains (2) summary
      smart00401
      Location:202247
      ZnF_GATA; zinc finger binding to DNA consensus sequence [AT]GATA[AG]
      cd00202
      Location:203249
      ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
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