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    CRLF2 cytokine receptor like factor 2 [ Homo sapiens (human) ]

    Gene ID: 64109, updated on 23-Jul-2017
    Official Symbol
    CRLF2provided by HGNC
    Official Full Name
    cytokine receptor like factor 2provided by HGNC
    Primary source
    HGNC:HGNC:14281
    See related
    Ensembl:ENSG00000205755 MIM:300357; MIM:400023; Vega:OTTHUMG00000067432
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRL2; TSLPR; CRLF2Y
    Summary
    This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
    Orthologs
    Location:
    Xp22.33 and Yp11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (1190437..1212762, complement)
    108 current GRCh38.p7 (GCF_000001405.33) Y NC_000024.10 (1190437..1212762, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (1314869..1331529, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (1264869..1281529, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene repetin pseudogene Neighboring gene 60S ribosomal protein L6-like Neighboring gene uncharacterized LOC107985697 Neighboring gene colony stimulating factor 2 receptor alpha subunit Neighboring gene microRNA 3690

    Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene repetin pseudogene Neighboring gene 60S ribosomal protein L6-like Neighboring gene uncharacterized LOC107985697 Neighboring gene colony stimulating factor 2 receptor alpha subunit Neighboring gene microRNA 3690

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of cytokine receptor-like factor 2 (CRLF2) in primary human brain microvascular endothelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway, organism-specific biosystem
      Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cytokine receptor-like factor 2
    Names
    IL-XR
    TSLP receptor
    cytokine receptor CRL2 precusor
    thymic stromal lymphopoietin protein receptor
    thymic stromal-derived lymphopoietin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034237.1 RefSeqGene

      Range
      5001..27228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001012288.2NP_001012288.2  cytokine receptor-like factor 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon which results in translation initiation at a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AF142570, AK026800, AY775789
      Consensus CDS
      CCDS75944.1
      UniProtKB/Swiss-Prot
      Q9HC73
      Related
      ENSP00000370979.4, ENST00000381567.8
      Conserved Domains (1) summary
      cd00063
      Location:776
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_022148.3NP_071431.2  cytokine receptor-like factor 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_071431.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AF142570, AK026800
      Consensus CDS
      CCDS75945.1
      UniProtKB/Swiss-Prot
      Q9HC73
      UniProtKB/TrEMBL
      D0E2W4
      Related
      ENSP00000383641.3, OTTHUMP00000070430, ENST00000400841.7, OTTHUMT00000144413
      Conserved Domains (1) summary
      cd00063
      Location:119207
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_110830.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon, lacks an alternate exon, and contains another alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF142570, AK026800
      Related
      ENST00000467626.6, OTTHUMT00000144414

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      1190437..1212762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011546181.2XP_011544483.1  cytokine receptor-like factor 2 isoform X1

      See identical proteins and their annotated locations for XP_011544483.1

      Conserved Domains (1) summary
      cd00063
      Location:118206
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_011546182.2XP_011544484.1  cytokine receptor-like factor 2 isoform X2

      See identical proteins and their annotated locations for XP_011544484.1

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000024.10 Reference GRCh38.p7 Primary Assembly

      Range
      1190437..1212762 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545634.2XP_011543936.1  cytokine receptor-like factor 2 isoform X1

      See identical proteins and their annotated locations for XP_011543936.1

      Conserved Domains (1) summary
      cd00063
      Location:118206
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. XM_011545635.2XP_011543937.1  cytokine receptor-like factor 2 isoform X2

      See identical proteins and their annotated locations for XP_011543937.1

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      1345456..1361668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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