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    CFLAR CASP8 and FADD like apoptosis regulator [ Homo sapiens (human) ]

    Gene ID: 8837, updated on 11-Jun-2017
    Official Symbol
    CFLARprovided by HGNC
    Official Full Name
    CASP8 and FADD like apoptosis regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:1876
    See related
    Ensembl:ENSG00000003402 MIM:603599; Vega:OTTHUMG00000132819
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CASH; FLIP; MRIT; CLARP; FLAME; Casper; FLAME1; c-FLIP; FLAME-1; I-FLICE; c-FLIPL; c-FLIPR; c-FLIPS; CASP8AP1
    Summary
    The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    2q33.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (201116015..201172688)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (201980877..202037411)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373836 Neighboring gene ribosomal protein L17 pseudogene 10 Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 10 Neighboring gene CFLAR antisense RNA 1 Neighboring gene RNA, U7 small nuclear 45 pseudogene Neighboring gene ribosomal protein L38 pseudogene Neighboring gene caspase 10 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 pseudogene 25 Neighboring gene mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 pseudogene 23

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of CASP8 and FADD-like apoptosis regulator (CFLAR) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Trafficking of HIV-1 gp120 to lipid rafts is blocked by expression of cFLIP PubMed
    env HIV-1 Env-pseudotyped virus-infected monocyte-derived macrophage cells downregulate expression of TRAIL decoy receptors DcR1 and DcR2, and cellular FLICE-inhibitory protein (c-FLIP) PubMed
    env c-FLIPL inhibits Bax activation via modulating PKC expression at the transcriptional level involving AP-2 during gp120 treatment PubMed
    capsid gag cFLIP-induced upregulation of TRIM-5alpha expression inhibits HIV-1 CA expression PubMed
    gag Trafficking of HIV-1 CA to lipid rafts is blocked by expression of cFLIP, which causes decreased levels of TSG101 and Alix at the plasma membrane PubMed

    Go to the HIV-1, Human Interaction Database

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from REACTOME)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
      Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
    • Autophagy - animal, organism-specific biosystem (from KEGG)
      Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • Autophagy - animal, conserved biosystem (from KEGG)
      Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
    • CASP8 activity is inhibited, organism-specific biosystem (from REACTOME)
      CASP8 activity is inhibited, organism-specific biosystemCell death triggered by extrinsic stimuli via death receptors or toll-like receptors (e.g., TLR3, TLR4) may result in either apoptosis or regulated necrosis (necroptosis) (Holler N et al. 2000; Kalai...
    • Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystem (from REACTOME)
      Caspase activation via extrinsic apoptotic signalling pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
    • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
      Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
    • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
      Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
    • Dimerization of procaspase-8, organism-specific biosystem (from REACTOME)
      Dimerization of procaspase-8, organism-specific biosystemProcaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become acc...
    • FAS (CD95) signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      FAS (CD95) signaling pathway, organism-specific biosystem
      FAS (CD95) signaling pathway
    • Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystem (from WikiPathways)
      Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
    • HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem (from Pathway Interaction Database)
      HIV-1 Nef: Negative effector of Fas and TNF-alpha, organism-specific biosystem
      HIV-1 Nef: Negative effector of Fas and TNF-alpha
    • Ligand-dependent caspase activation, organism-specific biosystem (from REACTOME)
      Ligand-dependent caspase activation, organism-specific biosystemCaspase-8 is synthesized as zymogen (procaspase-8) and is formed from procaspase-8 as a cleavage product. However, the cleavage itself appears not to be sufficient for the formation of an active casp...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Nanomaterial induced apoptosis, organism-specific biosystem (from WikiPathways)
      Nanomaterial induced apoptosis, organism-specific biosystemApotosis caused by nanomaterials, such as single-walled carbon nanohorns, titanium oxide, and polystyrene nanoparticles, may be induced through lysosomal impairment. For example, PAMAMs have been fou...
    • Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystemPhotodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) a...
    • Photodynamic therapy-induced NF-kB survival signaling, organism-specific biosystem (from WikiPathways)
      Photodynamic therapy-induced NF-kB survival signaling, organism-specific biosystemPhotodynamic therapy may induce a pro-inflammatory and angiogenic response mediated by NF-?B.
    • Programmed Cell Death, organism-specific biosystem (from REACTOME)
      Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
    • RIPK1-mediated regulated necrosis, organism-specific biosystem (from REACTOME)
      RIPK1-mediated regulated necrosis, organism-specific biosystemReceptor-interacting kinase protein 1 (RIPK1) and RIPK3-dependent necrosis is called necroptosis or programmed necrosis. The kinase activities of RIPK1 and RIPK3 are essential for the necroptotic cel...
    • Regulated Necrosis, organism-specific biosystem (from REACTOME)
      Regulated Necrosis, organism-specific biosystemNecrosis has traditionally been considered as a passive, unregulated cell death. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by genetically controlled and h...
    • Regulation by c-FLIP, organism-specific biosystem (from REACTOME)
      Regulation by c-FLIP, organism-specific biosystemc-FLIP proteins (CASP8 and FADD-like apoptosis regulators or c-FLICE inhibitory proteins) are death effector domain (DED)-containing proteins that are recruited to the death-inducing signaling comple...
    • Regulation of necroptotic cell death, organism-specific biosystem (from REACTOME)
      Regulation of necroptotic cell death, organism-specific biosystemA regulated balance between cell survival and cell death is essential for normal development and homeostasis of multicellular organisms. Defects in control of this balance may contribute to autoimmu...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
    • TNF signaling pathway, organism-specific biosystem (from KEGG)
      TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TNF signaling pathway, conserved biosystem (from KEGG)
      TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
    • TRAIL signaling, organism-specific biosystem (from REACTOME)
      TRAIL signaling, organism-specific biosystemTumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work throug...
    • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TRAIL signaling pathway, organism-specific biosystem
      TRAIL signaling pathway
    • Validated targets of C-MYC transcriptional repression, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional repression, organism-specific biosystem
      Validated targets of C-MYC transcriptional repression
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    death receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to dexamethasone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to estradiol stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nitric oxide IEA
    Inferred from Electronic Annotation
    more info
     
    execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular response to transforming growth factor beta stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
    Traceable Author Statement
    more info
     
    negative regulation of hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myoblast fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of glomerular mesangial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hepatocyte proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
    Traceable Author Statement
    more info
     
    regulation of necroptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of skeletal muscle satellite cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle atrophy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skeletal muscle tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skeletal muscle tissue regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    skeletal myofibril assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    CD95 death-inducing signaling complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    death-inducing signaling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    ripoptosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    CASP8 and FADD-like apoptosis regulator
    Names
    FADD-like antiapoptotic molecule 1
    MACH-related inducer of toxicity
    caspase homolog
    caspase-eight-related protein
    caspase-like apoptosis regulatory protein
    caspase-related inducer of apoptosis
    cellular FLICE-like inhibitory protein
    inhibitor of FLICE
    testis secretory sperm-binding protein Li 233m
    usurpin beta

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029005.1 RefSeqGene

      Range
      4951..61535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001127183.3NP_001120655.1  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_001120655.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS2337.1
      UniProtKB/Swiss-Prot
      O15519
      UniProtKB/TrEMBL
      A0A024R3Z7
      Related
      ENSP00000399420.2, OTTHUMP00000206480, ENST00000423241.6
      Conserved Domains (3) summary
      smart00115
      Location:244479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    2. NM_001127184.3NP_001120656.1  CASP8 and FADD-like apoptosis regulator isoform 2

      See identical proteins and their annotated locations for NP_001120656.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents use of an alternate coding exon that results in a shorter protein isoform (2) with a distinct C-terminus. Variants 3, 12, and 13 all encode the same isoform (2).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS46487.1
      UniProtKB/Swiss-Prot
      O15519
      Related
      ENSP00000339335.6, OTTHUMP00000206476, ENST00000341222.10
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    3. NM_001202515.1NP_001189444.1  CASP8 and FADD-like apoptosis regulator isoform 3

      See identical proteins and their annotated locations for NP_001189444.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC007283, AF041459, BM969271
      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (1) summary
      smart00115
      Location:1234
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    4. NM_001202516.2NP_001189445.1  CASP8 and FADD-like apoptosis regulator isoform 4

      See identical proteins and their annotated locations for NP_001189445.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS56157.1
      UniProtKB/Swiss-Prot
      O15519
      UniProtKB/TrEMBL
      A0A024R3Y3
      Related
      ENSP00000345807.6, OTTHUMP00000206478, ENST00000341582.10
      Conserved Domains (3) summary
      smart00115
      Location:209444
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    5. NM_001202517.2NP_001189446.1  CASP8 and FADD-like apoptosis regulator isoform 5

      See identical proteins and their annotated locations for NP_001189446.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (5) is shorter at the N-terminus compared to isoform 1. Variants 6, 14, and 15 all encode the same isoform (5).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS56158.1
      UniProtKB/Swiss-Prot
      O15519
      Related
      ENSP00000413270.1, OTTHUMP00000206475, ENST00000443227.5
      Conserved Domains (2) summary
      smart00115
      Location:148383
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    6. NM_001202518.1NP_001189447.1  CASP8 and FADD-like apoptosis regulator isoform 6

      See identical proteins and their annotated locations for NP_001189447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.
      Source sequence(s)
      AC007283, AK304585, BM969271, CD699251
      Consensus CDS
      CCDS59436.1
      UniProtKB/Swiss-Prot
      O15519
      UniProtKB/TrEMBL
      B4E361
      Related
      ENSP00000471805.1, OTTHUMP00000270978, ENST00000479953.6, OTTHUMT00000336706
      Conserved Domains (2) summary
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:148337
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    7. NM_001202519.2NP_001189448.1  CASP8 and FADD-like apoptosis regulator isoform 6

      See identical proteins and their annotated locations for NP_001189448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and coding sequence and the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1. Variants 7 and 8 both encode isoform 6.
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS59436.1
      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (2) summary
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:148337
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    8. NM_001308042.2NP_001294971.1  CASP8 and FADD-like apoptosis regulator isoform 7

      See identical proteins and their annotated locations for NP_001294971.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and contains an alternate 3' terminal exon, compared to variant 1, resulting in a novel 3' coding region and distinct 3' UTR. The resulting isoform (7) is shorter and has a distinct C-terminus compared to isoform 1. Variants 9 and 11 both encode the same isoform (7).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS77505.1
      UniProtKB/Swiss-Prot
      O15519
      Related
      ENSP00000411535.1, OTTHUMP00000206482, ENST00000457277.5
      Conserved Domains (3) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:244433
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    9. NM_001308043.1NP_001294972.1  CASP8 and FADD-like apoptosis regulator isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks multiple exons in the central and 3' coding regions, and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (8) is significantly shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AB209600, AC007283, DC375144
      Consensus CDS
      CCDS77503.1
      UniProtKB/TrEMBL
      E9PAP3, Q59F61
      Related
      ENSP00000378580.2, OTTHUMP00000206477, ENST00000395148.6, OTTHUMT00000336699
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    10. NM_001351590.1NP_001338519.1  CASP8 and FADD-like apoptosis regulator isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 9, encodes isoform 7.
      Source sequence(s)
      AC007283
    11. NM_001351591.1NP_001338520.1  CASP8 and FADD-like apoptosis regulator isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 3 and 13, encodes isoform 2.
      Source sequence(s)
      AC007283
    12. NM_001351592.1NP_001338521.1  CASP8 and FADD-like apoptosis regulator isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 3 and 12, encodes isoform 2.
      Source sequence(s)
      AC007283
    13. NM_001351593.1NP_001338522.1  CASP8 and FADD-like apoptosis regulator isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 6 and 15, encodes isoform 5.
      Source sequence(s)
      AC007283
    14. NM_001351594.1NP_001338523.1  CASP8 and FADD-like apoptosis regulator isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 6 and 14, encodes isoform 5.
      Source sequence(s)
      AC007283
    15. NM_003879.6NP_003870.4  CASP8 and FADD-like apoptosis regulator isoform 1

      See identical proteins and their annotated locations for NP_003870.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents use of an alternate first exon and encodes the longest protein isoform (1). Variants 1 and 2 both encode the same isoform (1).
      Source sequence(s)
      AC007283
      Consensus CDS
      CCDS2337.1
      UniProtKB/Swiss-Prot
      O15519
      UniProtKB/TrEMBL
      A0A024R3Z7
      Related
      ENSP00000312455.2, OTTHUMP00000163715, ENST00000309955.7
      Conserved Domains (3) summary
      smart00115
      Location:244479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    RNA

    1. NR_147241.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    2. NR_147242.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    3. NR_147243.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    4. NR_147244.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    5. NR_147245.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    6. NR_147246.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    7. NR_147247.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    8. NR_147248.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    9. NR_147249.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    10. NR_147250.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    11. NR_147251.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    12. NR_147252.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    13. NR_147253.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283
    14. NR_147255.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007283

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      201116015..201172688
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005196.1XP_016860685.1  CASP8 and FADD-like apoptosis regulator isoform X5

      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (1) summary
      smart00115
      Location:1234
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    2. XM_017005192.1XP_016860681.1  CASP8 and FADD-like apoptosis regulator isoform X3

      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (3) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:244433
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    3. XM_017005189.1XP_016860678.1  CASP8 and FADD-like apoptosis regulator isoform X1

    4. XM_017005195.1XP_016860684.1  CASP8 and FADD-like apoptosis regulator isoform X4

      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (2) summary
      smart00115
      Location:148383
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08340
      Location:175
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    5. XM_017005193.1XP_016860682.1  CASP8 and FADD-like apoptosis regulator isoform X3

      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (3) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:244433
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    6. XM_017005197.1XP_016860686.1  CASP8 and FADD-like apoptosis regulator isoform X6

      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    7. XM_017005191.1XP_016860680.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/Swiss-Prot
      O15519
      UniProtKB/TrEMBL
      A0A024R3Z7
      Conserved Domains (3) summary
      smart00115
      Location:244479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    8. XM_017005194.1XP_016860683.1  CASP8 and FADD-like apoptosis regulator isoform X3

      UniProtKB/Swiss-Prot
      O15519
      Conserved Domains (3) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
      cl00042
      Location:244433
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    9. XM_017005190.1XP_016860679.1  CASP8 and FADD-like apoptosis regulator isoform X2

      UniProtKB/Swiss-Prot
      O15519
      UniProtKB/TrEMBL
      A0A024R3Z7
      Conserved Domains (3) summary
      smart00115
      Location:244479
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein
    10. XM_017005198.1XP_016860687.1  CASP8 and FADD-like apoptosis regulator isoform X6

      UniProtKB/Swiss-Prot
      O15519
      Related
      ENSP00000406775.1, OTTHUMP00000207360, ENST00000440180.5, OTTHUMT00000336704
      Conserved Domains (2) summary
      cd08337
      Location:180
      DED_c-FLIP_r1; Death Effector Domain, repeat 1, of cellular FLICE-Inhibitory Protein
      cd08340
      Location:91171
      DED_c-FLIP_r2; Death Effector Domain, repeat 2, of cellular FLICE-Inhibitory Protein

    RNA

    1. XR_001739013.1 RNA Sequence

    2. XR_001739014.1 RNA Sequence

    3. XR_001739012.1 RNA Sequence

    4. XR_001739017.1 RNA Sequence

    5. XR_001739015.1 RNA Sequence

    6. XR_001739016.1 RNA Sequence

    7. XR_001739018.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      201986792..202043389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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