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    Brd4 bromodomain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 57261, updated on 9-Apr-2017
    Official Symbol
    Brd4provided by MGI
    Official Full Name
    bromodomain containing 4provided by MGI
    Primary source
    MGI:MGI:1888520
    See related
    Ensembl:ENSMUSG00000024002 Vega:OTTMUSG00000030241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brd5; MCAP; HUNK1; WI-11513
    Summary
    This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    17 B1; 17 17.39 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (32196272..32284722, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (32333219..32421068, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene notch 3 Neighboring gene predicted gene, 41568 Neighboring gene epoxide hydrolase 3 Neighboring gene predicted gene 4432 Neighboring gene A kinase (PRKA) anchor protein 8 Neighboring gene A kinase (PRKA) anchor protein 8-like

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP-dependent protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II C-terminal domain phosphoserine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II carboxy-terminal domain kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II carboxy-terminal domain kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    RNA polymerase II core binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K14 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone H4-K12 acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner cell mass cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulation of transcription involved in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    DNA-directed RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin/CDK positive transcription elongation factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    bromodomain-containing protein 4
    Names
    bromodomain-containing 5
    fsh-like protein
    mitotic chromosome-associated protein
    NP_001273559.1
    NP_065254.3
    NP_932762.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286630.1NP_001273559.1  bromodomain-containing protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001273559.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AK147545, BY779550, CJ192204
      Consensus CDS
      CCDS70784.1
      UniProtKB/TrEMBL
      Q3UH70
      Related
      ENSMUSP00000003726.8, ENSMUST00000003726.14
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13591401
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    2. NM_020508.4NP_065254.3  bromodomain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_065254.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) has two alternate splice sites, one in the 5' UTR and one in the 5' coding region, compared to variant 3. The resulting isoform (1) lacks an internal aa, compared to isoform 3.
      Source sequence(s)
      AK147545, BY779550, CJ192204
      Consensus CDS
      CCDS50057.1
      UniProtKB/Swiss-Prot
      Q9ESU6
      UniProtKB/TrEMBL
      Q3UH70
      Related
      ENSMUSP00000113070.1, OTTMUSP00000039144, ENSMUST00000121285.7, OTTMUST00000074872
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13581400
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    3. NM_198094.2NP_932762.2  bromodomain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_932762.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has two alternate splice sites, one in the 5' UTR and one in the 5' coding region, and also lacks several exons but includes an alternate 3' terminal exon, compared to variant 3. The resulting isoform (2) lacks an internal aa, and has a shorter and distinct C-terminus, compared to isoform 3.
      Source sequence(s)
      AF461396, BC138834, BY779550
      Consensus CDS
      CCDS37554.1
      UniProtKB/Swiss-Prot
      Q9ESU6
      UniProtKB/TrEMBL
      B2RSE4
      Related
      ENSMUSP00000110119.2, ENSMUST00000114475.8
      Conserved Domains (3) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      32196272..32284722 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524691.1XP_006524754.1  bromodomain-containing protein 4 isoform X4

      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13251367
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    2. XM_006524688.1XP_006524751.1  bromodomain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006524751.1

      UniProtKB/Swiss-Prot
      Q9ESU6
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13581400
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    3. XM_006524690.2XP_006524753.1  bromodomain-containing protein 4 isoform X3

      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13261368
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    4. XM_006524683.2XP_006524746.1  bromodomain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006524746.1

      UniProtKB/TrEMBL
      Q3UH70
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13591401
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    5. XM_006524689.2XP_006524752.1  bromodomain-containing protein 4 isoform X2

      See identical proteins and their annotated locations for XP_006524752.1

      UniProtKB/Swiss-Prot
      Q9ESU6
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:354455
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:610674
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13581400
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    6. XM_006524684.2XP_006524747.1  bromodomain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006524747.1

      UniProtKB/TrEMBL
      Q3UH70
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13591401
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    7. XM_017317588.1XP_017173077.1  bromodomain-containing protein 4 isoform X5

      Conserved Domains (3) summary
      cd05498
      Location:207308
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:463527
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:12111253
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    8. XM_006524693.2XP_006524756.1  bromodomain-containing protein 4 isoform X6

      Conserved Domains (3) summary
      cd05498
      Location:206307
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:462526
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:12101252
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    9. XM_006524686.1XP_006524749.1  bromodomain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006524749.1

      UniProtKB/TrEMBL
      Q3UH70
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13591401
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    10. XM_006524685.1XP_006524748.1  bromodomain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006524748.1

      UniProtKB/TrEMBL
      Q3UH70
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13591401
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    11. XM_006524687.2XP_006524750.1  bromodomain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006524750.1

      UniProtKB/TrEMBL
      Q3UH70
      Conserved Domains (4) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:13591401
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    12. XM_011246543.2XP_011244845.1  bromodomain-containing protein 4 isoform X5

      See identical proteins and their annotated locations for XP_011244845.1

      Conserved Domains (3) summary
      cd05498
      Location:207308
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:463527
      BET; Bromodomain extra-terminal - transcription regulation
      pfam17105
      Location:12111253
      BRD4_CDT; C-terminal domain of bromodomain protein 4
    13. XM_006524695.3XP_006524758.1  bromodomain-containing protein 4 isoform X7

      Related
      ENSMUSP00000112474.1, OTTMUSP00000039146, ENSMUST00000120276.7, OTTMUST00000074874
      Conserved Domains (3) summary
      cd05497
      Location:58164
      Bromo_Brdt_I_like; Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      cd05498
      Location:355456
      Bromo_Brdt_II_like; Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino ...
      pfam17035
      Location:611675
      BET; Bromodomain extra-terminal - transcription regulation
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