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    G6pdx glucose-6-phosphate dehydrogenase X-linked [ Mus musculus (house mouse) ]

    Gene ID: 14381, updated on 22-Apr-2017
    Official Symbol
    G6pdxprovided by MGI
    Official Full Name
    glucose-6-phosphate dehydrogenase X-linkedprovided by MGI
    Primary source
    MGI:MGI:105979
    See related
    Ensembl:ENSMUSG00000031400 Vega:OTTMUSG00000017699
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G28A; G6pd; Gpdx
    Orthologs
    Location:
    X A7.3; X 38.0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (74409486..74429161, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (71654825..71674500, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene family with sequence similarity 3, member A Neighboring gene inhibitor of kappaB kinase gamma Neighboring gene predicted gene 6880 Neighboring gene ribosomal protein S2 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    glucose binding ISO
    Inferred from Sequence Orthology
    more info
     
    glucose-6-phosphate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose-6-phosphate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose-6-phosphate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    NADP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NADPH regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte maturation ISO
    Inferred from Sequence Orthology
    more info
     
    glucose 6-phosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-10 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-12 production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell growth involved in cardiac muscle cell development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein glutathionylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process ISO
    Inferred from Sequence Orthology
    more info
     
    pentose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    pentose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pentose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    pentose-phosphate shunt, oxidative branch ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ribose phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glucose-6-phosphate 1-dehydrogenase X
    NP_032088.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008062.2NP_032088.1  glucose-6-phosphate 1-dehydrogenase X

      See identical proteins and their annotated locations for NP_032088.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075663
      Consensus CDS
      CCDS30232.1
      UniProtKB/Swiss-Prot
      Q00612
      UniProtKB/TrEMBL
      Q790Y8
      Related
      ENSMUSP00000004327.4, OTTMUSP00000019282, ENSMUST00000004327.10, OTTMUST00000042897
      Conserved Domains (3) summary
      TIGR00871
      Location:30506
      zwf; glucose-6-phosphate 1-dehydrogenase
      pfam00479
      Location:35209
      G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
      pfam02781
      Location:212503
      G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      74409486..74429161 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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