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    MAP3K2 mitogen-activated protein kinase kinase kinase 2 [ Homo sapiens (human) ]

    Gene ID: 10746, updated on 24-Nov-2016
    Official Symbol
    MAP3K2provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:6854
    See related
    Ensembl:ENSG00000169967 HPRD:10068; MIM:609487; Vega:OTTHUMG00000153397
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MEKK2; MEKK2B
    Summary
    The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q14.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (127298669..127343229, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (128056245..128100805, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WW domain binding protein 11 pseudogene Neighboring gene ERCC excision repair 3, TFIIH core complex helicase subunit Neighboring gene RNA, U6 small nuclear 1147, pseudogene Neighboring gene uncharacterized LOC105373606 Neighboring gene uncharacterized LOC100506922

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies MAP3K2, a member of mitogen-activated protein kinase kinase family (serine/threonine protein kinase), is important for HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transducer, downstream of receptor, with serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    activation of JUN kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of MAPK activity TAS
    Traceable Author Statement
    more info
    PubMed 
    activation of MAPKK activity IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    Preferred Names
    mitogen-activated protein kinase kinase kinase 2
    Names
    MAP/ERK kinase kinase 2
    MAPK/ERK kinase kinase 2
    MEK kinase 2
    MEKK 2
    NP_006600.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006609.4NP_006600.3  mitogen-activated protein kinase kinase kinase 2

      See identical proteins and their annotated locations for NP_006600.3

      Status: REVIEWED

      Source sequence(s)
      AC068282, AC110926, BC136293
      Consensus CDS
      CCDS46404.1
      UniProtKB/Swiss-Prot
      Q9Y2U5
      UniProtKB/TrEMBL
      A0A024RAH0
      Related
      ENSP00000343463, OTTHUMP00000203818, ENST00000344908, OTTHUMT00000331015
      Conserved Domains (3) summary
      cd06405
      Location:44122
      PB1_Mekk2_3; The PB1 domain is present in the two mitogen-activated protein kinase kinases MEKK2 and MEKK3 which are two members of the signaling kinase cascade involved in angiogenesis and early cardiovascular development. The PB1 domain of MEKK2 (and/or MEKK3) ...
      smart00220
      Location:356613
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06652
      Location:353616
      STKc_MEKK2; Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      127298669..127343229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      128060819..128105372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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