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    Ddr2 discoidin domain receptor family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 18214, updated on 4-Feb-2018
    Official Symbol
    Ddr2provided by MGI
    Official Full Name
    discoidin domain receptor family, member 2provided by MGI
    Primary source
    MGI:MGI:1345277
    See related
    Ensembl:ENSMUSG00000026674 Vega:OTTMUSG00000049937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntrkr3; tyro10; AW495251
    Expression
    Biased expression in bladder adult (RPKM 28.6), limb E14.5 (RPKM 18.7) and 13 other tissues See more
    Orthologs
    Location:
    1 H3; 1 76.84 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (169972307..170110843, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (171902438..172019075, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 190 Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 Neighboring gene U2AF homology motif (UHM) kinase 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    collagen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    collagen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase collagen receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein tyrosine kinase collagen receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein tyrosine kinase collagen receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    signal transducer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    biomineral tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen fibril organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    collagen-activated tyrosine kinase receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen-activated tyrosine kinase receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    endochondral bone growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of osteoblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of bone mineralization ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    discoidin domain-containing receptor 2
    Names
    CD167 antigen-like family member B
    discoidin domain receptor 2
    neurotrophic tyrosine kinase, receptor-related 3
    receptor protein-tyrosine kinase TKT
    tyrosine-protein kinase TYRO10
    NP_072075.2
    XP_006496759.1
    XP_006496760.1
    XP_006496761.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022563.2NP_072075.2  discoidin domain-containing receptor 2 precursor

      See identical proteins and their annotated locations for NP_072075.2

      Status: VALIDATED

      Source sequence(s)
      AC139673, AI838577, X76505
      Consensus CDS
      CCDS48436.1
      UniProtKB/Swiss-Prot
      Q62371
      Related
      ENSMUSP00000129624.1, ENSMUST00000170800.7
      Conserved Domains (4) summary
      smart00221
      Location:563848
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:32184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:557850
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      169972307..170110843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496696.3XP_006496759.1  discoidin domain-containing receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_006496759.1

      UniProtKB/Swiss-Prot
      Q62371
      Conserved Domains (4) summary
      smart00221
      Location:563848
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:32184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:557850
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006496697.3XP_006496760.1  discoidin domain-containing receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_006496760.1

      UniProtKB/Swiss-Prot
      Q62371
      Related
      ENSMUSP00000141443.1, OTTMUSP00000068667, ENSMUST00000194690.5, OTTMUST00000127112
      Conserved Domains (4) summary
      smart00221
      Location:563848
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:32184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:557850
      PKc_like; Protein Kinases, catalytic domain
    3. XM_006496698.3XP_006496761.1  discoidin domain-containing receptor 2 isoform X1

      See identical proteins and their annotated locations for XP_006496761.1

      UniProtKB/Swiss-Prot
      Q62371
      Related
      ENSMUSP00000027985.2, ENSMUST00000027985.7
      Conserved Domains (4) summary
      smart00221
      Location:563848
      STYKc; Protein kinase; unclassified specificity
      smart00231
      Location:30185
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
      cd00057
      Location:32184
      FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
      cl21453
      Location:557850
      PKc_like; Protein Kinases, catalytic domain
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