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    Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha [ Mus musculus (house mouse) ]

    Gene ID: 13665, updated on 22-Apr-2017
    Official Symbol
    Eif2s1provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2, subunit 1 alphaprovided by MGI
    Primary source
    MGI:MGI:95299
    See related
    Ensembl:ENSMUSG00000021116 Vega:OTTMUSG00000031427
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    35kDa; Eif2a; eIF2alpha; 0910001O23Rik; 2410026C18Rik
    Orthologs
    Location:
    12; 12 C3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 12 NC_000078.6 (78862072..78887010)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (79963059..79987997)

    Chromosome 12 - NC_000078.6Genomic Context describing neighboring genes Neighboring gene membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit D Neighboring gene pleckstrin 2 Neighboring gene predicted gene, 46359 Neighboring gene predicted gene, 46360

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ribosome binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aging ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to UV IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to amino acid starvation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of translational initiation in response to stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    eukaryotic 48S preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    eukaryotic translation initiation factor 2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    colocalizes_with eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    glial limiting end-foot ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    multi-eIF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    translation initiation ternary complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    eukaryotic translation initiation factor 2 subunit 1
    Names
    eIF-2-alpha
    eIF-2A
    eIF-2alpha
    eukaryotic translation initiation factor 2 subunit alpha
    eukaryotic translation initiation factor 2A

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026114.3NP_080390.1  eukaryotic translation initiation factor 2 subunit 1

      See identical proteins and their annotated locations for NP_080390.1

      Status: PROVISIONAL

      Source sequence(s)
      AK143499
      Consensus CDS
      CCDS26003.1
      UniProtKB/Swiss-Prot
      Q6ZWX6
      Related
      ENSMUSP00000071214.7, OTTMUSP00000041277, ENSMUST00000071230.7, OTTMUST00000077865
      Conserved Domains (3) summary
      cd04452
      Location:1489
      S1_IF2_alpha; S1_IF2_alpha: The alpha subunit of translation Initiation Factor 2, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. Eukaryotic and archaeal Initiation Factor 2 (e- and aIF2, respectively) ...
      PTZ00248
      Location:4315
      PTZ00248; eukaryotic translation initiation factor 2 subunit 1; Provisional
      pfam07541
      Location:132241
      EIF_2_alpha; Eukaryotic translation initiation factor 2 alpha subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000078.6 Reference GRCm38.p4 C57BL/6J

      Range
      78862072..78887010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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