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    Fgf10 fibroblast growth factor 10 [ Mus musculus (house mouse) ]

    Gene ID: 14165, updated on 16-Jan-2018
    Official Symbol
    Fgf10provided by MGI
    Official Full Name
    fibroblast growth factor 10provided by MGI
    Primary source
    MGI:MGI:1099809
    See related
    Ensembl:ENSMUSG00000021732 Vega:OTTMUSG00000032890
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AEY17; Fgf-10; BB213776; Gsfaey17
    Expression
    Broad expression in subcutaneous fat pad adult (RPKM 4.8), mammary gland adult (RPKM 3.9) and 15 other tissues See more
    Orthologs
    Location:
    13 D2.3; 13 67.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (118714699..118792573)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (119503506..119581380)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene phospholipid scramblase 3 pseudogene Neighboring gene predicted gene 10732 Neighboring gene predicted gene 16263 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene polyadenylate binding protein-interacting protein 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chemoattractant activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemoattractant activity ISO
    Inferred from Sequence Orthology
    more info
     
    fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    type 2 fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Harderian gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Type II pneumocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    animal organ morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branch elongation involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching morphogenesis of an epithelial tube ISO
    Inferred from Sequence Orthology
    more info
     
    bronchiole morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bud elongation involved in lung branching IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    bud outgrowth involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermis morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial cell proliferation involved in salivary gland morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial cell proliferation involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    establishment of mitotic spindle orientation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    female genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    fibroblast growth factor receptor signaling pathway involved in mammary gland specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway involved in mammary gland specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fibroblast growth factor receptor signaling pathway involved in mammary gland specification ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    induction of positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lacrimal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lacrimal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    limb bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung alveolus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung alveolus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung proximal/distal axis specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lung saccule development ISO
    Inferred from Sequence Orthology
    more info
     
    male genitalia morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mesenchymal cell differentiation involved in lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mesenchymal-epithelial cell signaling involved in lung development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metanephros morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    muscle cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    organ induction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    organ induction ISO
    Inferred from Sequence Orthology
    more info
     
    otic vesicle formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    otic vesicle formation TAS
    Traceable Author Statement
    more info
    PubMed 
    pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ERK1 and ERK2 cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of fibroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hair follicle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lymphocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of urothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of white fat cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    prostatic bud formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    radial glial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of activin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of saliva secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory system development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    salivary gland development ISO
    Inferred from Sequence Orthology
    more info
     
    salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secretion by lung epithelial cell involved in lung growth ISO
    Inferred from Sequence Orthology
    more info
     
    semicircular canal fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    semicircular canal morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    submandibular salivary gland formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tear secretion ISO
    Inferred from Sequence Orthology
    more info
     
    thymus development ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    urothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    white fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    fibroblast growth factor 10
    Names
    keratinocyte growth factor 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008002.4NP_032028.1  fibroblast growth factor 10 precursor

      See identical proteins and their annotated locations for NP_032028.1

      Status: VALIDATED

      Source sequence(s)
      AK045267, BB487015, BC048229
      Consensus CDS
      CCDS26795.1
      UniProtKB/Swiss-Prot
      O35565
      Related
      ENSMUSP00000022246.8, OTTMUSP00000043898, ENSMUST00000022246.8, OTTMUST00000081954
      Conserved Domains (1) summary
      smart00442
      Location:77205
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      118714699..118792573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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