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    Bbc3 BCL2 binding component 3 [ Mus musculus (house mouse) ]

    Gene ID: 170770, updated on 12-Mar-2017
    Official Symbol
    Bbc3provided by MGI
    Official Full Name
    BCL2 binding component 3provided by MGI
    Primary source
    MGI:MGI:2181667
    See related
    Ensembl:ENSMUSG00000002083 Vega:OTTMUSG00000022267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PUMA; PUMA/JFY1
    Orthologs
    Location:
    7; 7 A2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (16308320..16318334)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (16894932..16903683)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene complement component 5a receptor 1 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene SUMO1 activating enzyme subunit 1 Neighboring gene zinc finger CCCH-type containing 4

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis, organism-specific biosystem (from WikiPathways)
      Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
    • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
      Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Apoptosis - multiple species, conserved biosystem (from KEGG)
      Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
    • Hippo signaling pathway, organism-specific biosystem (from KEGG)
      Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Hippo signaling pathway, conserved biosystem (from KEGG)
      Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Platinum drug resistance, organism-specific biosystem (from KEGG)
      Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • Platinum drug resistance, conserved biosystem (from KEGG)
      Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    • p53 signaling, organism-specific biosystem (from WikiPathways)
      p53 signaling, organism-specific biosystemhttp://www.kegg.jp/ (mmu04115) p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcription...
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    glycoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to DNA damage stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to ionizing radiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
     
    execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of endoplasmic reticulum calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of growth ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cysteine-type endopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of thymocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    release of cytochrome c from mitochondria ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    toxin transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with lysosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrial envelope ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    bcl-2-binding component 3
    Names
    BH3-only
    Bcl-2 binding component 3
    p53 up-regulated modulator of apoptosis

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133234.2NP_573497.1  bcl-2-binding component 3

      See identical proteins and their annotated locations for NP_573497.1

      Status: VALIDATED

      Source sequence(s)
      AC156630
      Consensus CDS
      CCDS20847.1
      UniProtKB/Swiss-Prot
      Q99ML1
      UniProtKB/TrEMBL
      B2RVL4
      Related
      ENSMUSP00000002152, OTTMUSP00000025190, ENSMUST00000002152, OTTMUST00000053027
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      16308320..16318334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539578.3XP_006539641.1  bcl-2-binding component 3 isoform X2

      See identical proteins and their annotated locations for XP_006539641.1

      UniProtKB/Swiss-Prot
      Q99ML1
      UniProtKB/TrEMBL
      B2RVL4
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    2. XM_006539582.2XP_006539645.1  bcl-2-binding component 3 isoform X2

      See identical proteins and their annotated locations for XP_006539645.1

      UniProtKB/Swiss-Prot
      Q99ML1
      UniProtKB/TrEMBL
      B2RVL4
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    3. XM_006539579.3XP_006539642.1  bcl-2-binding component 3 isoform X2

      See identical proteins and their annotated locations for XP_006539642.1

      UniProtKB/Swiss-Prot
      Q99ML1
      UniProtKB/TrEMBL
      B2RVL4
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    4. XM_006539577.3XP_006539640.1  bcl-2-binding component 3 isoform X2

      See identical proteins and their annotated locations for XP_006539640.1

      UniProtKB/Swiss-Prot
      Q99ML1
      UniProtKB/TrEMBL
      B2RVL4
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    5. XM_006539575.3XP_006539638.1  bcl-2-binding component 3 isoform X1

      Conserved Domains (1) summary
      pfam15826
      Location:18209
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    6. XM_006539581.1XP_006539644.1  bcl-2-binding component 3 isoform X2

      See identical proteins and their annotated locations for XP_006539644.1

      UniProtKB/Swiss-Prot
      Q99ML1
      UniProtKB/TrEMBL
      B2RVL4
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    7. XM_006539580.2XP_006539643.1  bcl-2-binding component 3 isoform X2

      See identical proteins and their annotated locations for XP_006539643.1

      UniProtKB/Swiss-Prot
      Q99ML1
      UniProtKB/TrEMBL
      B2RVL4
      Conserved Domains (1) summary
      pfam15826
      Location:2193
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
    8. XM_006539583.3XP_006539646.1  bcl-2-binding component 3 isoform X3

      Conserved Domains (1) summary
      pfam15826
      Location:29122
      PUMA; Bcl-2-binding component 3, p53 upregulated modulator of apoptosis
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