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    mrcB fused glycosyl transferase and transpeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944843, updated on 6-Sep-2017
    Gene symbol
    mrcB
    Gene description
    fused glycosyl transferase and transpeptidase
    Primary source
    EcoGene:EG10605
    Locus tag
    b0149
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0148; JW0145; pbpF; ponB
    Summary
    MrcB is part of a complex with MltA and MipA. [More information is available at EcoGene: EG10605]. The murein sacculus (peptidoglycan) is a polymer made up of long chains of alternating N-acetylglucosamine and N-acetylmuramic acid residues crosslinked by peptide side chains. [More information is available at EcoCyc: EG10605].
    Sequence:
    NC_000913.3 (164730..167264)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 2'-5' RNA ligase Neighboring gene putative ATP-dependent helicase Neighboring gene ferrichrome outer membrane transporter Neighboring gene iron(3+)-hydroxamate import ABC transporter ATPase Neighboring gene iron(3+)-hydroxamate import ABC transporter periplasmic binding protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Peptidoglycan biosynthesis, organism-specific biosystem (from KEGG)
      Peptidoglycan biosynthesis, organism-specific biosystemPeptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typica...
    • Peptidoglycan biosynthesis, conserved biosystem (from KEGG)
      Peptidoglycan biosynthesis, conserved biosystemPeptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typica...
    • peptidoglycan maturation (meso-diaminopimelate containing), organism-specific biosystem (from BIOCYC)
      peptidoglycan maturation (meso-diaminopimelate containing), organism-specific biosystemThe peptidoglycan (PG) or murein sacculus of E. coli K-12 is assembled from monomer subunits of the disaccharide pentapeptide, N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-glutamyl-meso-2...
    • peptidoglycan maturation (meso-diaminopimelate containing), conserved biosystem (from BIOCYC)
      peptidoglycan maturation (meso-diaminopimelate containing), conserved biosystemThe peptidoglycan (PG) or murein sacculus of E. coli K-12 is assembled from monomer subunits of the disaccharide pentapeptide, N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-gamma-D-glutamyl-meso-2...
    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipopeptide binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    penicillin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidoglycan glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    serine-type D-Ala-D-Ala carboxypeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    serine-type D-Ala-D-Ala carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    peptidoglycan biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidoglycan biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    peptidoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to antibiotic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    fused glycosyl transferase and transpeptidase
    NP_414691.1
    • peptidoglycan synthetase; penicillin-binding protein 1B

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      164730..167264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414691.1 fused glycosyl transferase and transpeptidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414691.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P02919
      Conserved Domains (1) summary
      PRK09506
      Location:1843
      mrcB; bifunctional glycosyl transferase/transpeptidase; Reviewed
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