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    Iapp islet amyloid polypeptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24476, updated on 22-Apr-2017
    Official Symbol
    Iappprovided by RGD
    Official Full Name
    islet amyloid polypeptideprovided by RGD
    Primary source
    RGD:2854
    See related
    Ensembl:ENSRNOG00000012417
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    pancreatic islet hormone found in the pancreatic amyloid deposits [RGD, Feb 2006]
    Orthologs
    Location:
    4q44
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (176509863..176517903)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (240723950..240731446)

    Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene kidney specific organic anion transporter Neighboring gene solute carrier organic anion transporter family, member 1a6 Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene uncharacterized LOC102549024 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene RecQ like helicase

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    hormone activity TAS
    Traceable Author Statement
    more info
    PubMed 
    identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of bone resorption IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
     
    sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    islet amyloid polypeptide
    Names
    DAP
    amylin
    diabetes-associated peptide

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012586.2NP_036718.1  islet amyloid polypeptide precursor

      See identical proteins and their annotated locations for NP_036718.1

      Status: PROVISIONAL

      Source sequence(s)
      X52820
      UniProtKB/Swiss-Prot
      P12969
      Conserved Domains (1) summary
      smart00113
      Location:3677
      CALCITONIN; calcitonin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

      Range
      176509863..176517903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237614.3XP_006237676.1  islet amyloid polypeptide isoform X1

      See identical proteins and their annotated locations for XP_006237676.1

      UniProtKB/Swiss-Prot
      P12969
      Related
      ENSRNOP00000016614.1, ENSRNOT00000016614.4
      Conserved Domains (1) summary
      smart00113
      Location:3677
      CALCITONIN; calcitonin

    Alternate Rn_Celera

    Genomic

    1. AC_000072.1 Alternate Rn_Celera

      Range
      163770383..163775298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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