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    CHIA chitinase, acidic [ Homo sapiens (human) ]

    Gene ID: 27159, updated on 4-Feb-2018
    Official Symbol
    CHIAprovided by HGNC
    Official Full Name
    chitinase, acidicprovided by HGNC
    Primary source
    HGNC:HGNC:17432
    See related
    Ensembl:ENSG00000134216 MIM:606080; Vega:OTTHUMG00000011165
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHIT2; AMCASE; TSA1902
    Summary
    The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
    Expression
    Biased expression in stomach (RPKM 2.7), lung (RPKM 1.9) and 2 other tissues See more
    Orthologs
    Location:
    1p13.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (111290852..111320566)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (111833474..111863188)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chitinase, acidic pseudogene 1 Neighboring gene chitinase, acidic pseudogene 2 Neighboring gene uncharacterized LOC105378903 Neighboring gene primary cilia formation

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp313J1722

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    carbohydrate binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chitin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    chitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chitinase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chitinase activity TAS
    Traceable Author Statement
    more info
     
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    lysozyme activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell wall chitin metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    chitin catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chitin catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    chitin metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    digestion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    polysaccharide digestion TAS
    Traceable Author Statement
    more info
     
    positive regulation of chemokine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    production of molecular mediator involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to fungus TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IC
    Inferred by Curator
    more info
    PubMed 
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    acidic mammalian chitinase
    Names
    lung-specific protein TSA1902
    NP_001035713.1
    NP_001244930.1
    NP_001244931.1
    NP_001244932.1
    NP_001244933.1
    NP_001244934.1
    NP_068569.2
    NP_970615.2
    XP_006710640.1
    XP_016856536.1
    XP_016856537.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040623.2NP_001035713.1  acidic mammalian chitinase isoform b

      See identical proteins and their annotated locations for NP_001035713.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks exons in the 5' end of the coding region compared to variant 4. The resulting isoform (b, also known as TSA1902-S) is shorter at the N-terminus compared to isoform a. Variants 3, 6, 8, and 9 all encode the same isoform (b).
      Source sequence(s)
      AB025008, AF290004, AK290702, AY789445, BC036339
      Consensus CDS
      CCDS58017.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7
      Conserved Domains (3) summary
      smart00494
      Location:268315
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1204
      Glyco_18; Glyco_18 domain
      cl10447
      Location:1226
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    2. NM_001258001.1NP_001244930.1  acidic mammalian chitinase isoform a

      See identical proteins and their annotated locations for NP_001244930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an exon in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (a, also known as TSA1902-L) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 2, 5, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK290702, AL513202, BC036339
      Consensus CDS
      CCDS832.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7
      Conserved Domains (2) summary
      cd02872
      Location:1279
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:321368
      ChtBD2; Chitin-binding domain type 2
    3. NM_001258002.1NP_001244931.1  acidic mammalian chitinase isoform b

      See identical proteins and their annotated locations for NP_001244931.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks exons in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (b, also known as TSA1902-S) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 3, 6, 8, and 9 all encode the same isoform (b).
      Source sequence(s)
      AB025009, AK290702, AL356387, BC036339
      Consensus CDS
      CCDS58017.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7
      Related
      ENSP00000436946.1, OTTHUMP00000233469, ENST00000483391.5, OTTHUMT00000030715
      Conserved Domains (3) summary
      smart00494
      Location:268315
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1204
      Glyco_18; Glyco_18 domain
      cl10447
      Location:1226
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    4. NM_001258003.1NP_001244932.1  acidic mammalian chitinase isoform a

      See identical proteins and their annotated locations for NP_001244932.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks exons in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (a, also known as TSA1902-L) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 2, 5, and 7 all encode the same isoform (a).
      Source sequence(s)
      AK290702, AY825504, BC036339
      Consensus CDS
      CCDS832.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7, Q2VT96
      Conserved Domains (2) summary
      cd02872
      Location:1279
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:321368
      ChtBD2; Chitin-binding domain type 2
    5. NM_001258004.1NP_001244933.1  acidic mammalian chitinase isoform b

      See identical proteins and their annotated locations for NP_001244933.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an exon and contains another exon in the 5' coding region, initiating translation at a downstream AUG compared to variant 4. The encoded isoform (b, also known as TSA1902-S) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 3, 6, 8, and 9 all encode the same isoform (b).
      Source sequence(s)
      AB025008, AF290004, AK290702, AL356387, AY911310, BC036339
      Consensus CDS
      CCDS58017.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7, Q1M0P4
      Conserved Domains (3) summary
      smart00494
      Location:268315
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1204
      Glyco_18; Glyco_18 domain
      cl10447
      Location:1226
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    6. NM_001258005.1NP_001244934.1  acidic mammalian chitinase isoform b

      See identical proteins and their annotated locations for NP_001244934.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks exons and contains another exon in the 5' coding region, initiating translation at a downstream AUG compared to variant 4. The encoded isoform (b, also known as TSA1902-S) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 3, 6, 8, and 9 all encode the same isoform (b).
      Source sequence(s)
      AB025008, AF290004, AK290702, AL356387, AY911311, BC036339
      Consensus CDS
      CCDS58017.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7, Q1M0P3
      Related
      ENSP00000338970.7, OTTHUMP00000233471, ENST00000353665.10, OTTHUMT00000390453
      Conserved Domains (3) summary
      smart00494
      Location:268315
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1204
      Glyco_18; Glyco_18 domain
      cl10447
      Location:1226
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    7. NM_021797.3NP_068569.2  acidic mammalian chitinase isoform a

      See identical proteins and their annotated locations for NP_068569.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks exons in the 5' coding region and initiates translation at a downstream AUG compared to variant 4. The encoded isoform (a, also known as TSA1902-L) has a shorter N-terminus and lacks a signal peptide compared to isoform c. Variants 2, 5, and 7 all encode the same isoform (a).
      Source sequence(s)
      AB025008, AK290702, BC036339
      Consensus CDS
      CCDS832.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7
      Related
      ENSP00000387671.1, OTTHUMP00000012866, ENST00000422815.5, OTTHUMT00000030714
      Conserved Domains (2) summary
      cd02872
      Location:1279
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:321368
      ChtBD2; Chitin-binding domain type 2
    8. NM_201653.3NP_970615.2  acidic mammalian chitinase isoform c precursor

      See identical proteins and their annotated locations for NP_970615.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (c). Version 1 of this RefSeq represented a distinct variant (1) encoding a different isoform (a).
      Source sequence(s)
      AB025008, AF290004, AK290702, AL513202, BC036339
      Consensus CDS
      CCDS41368.1
      UniProtKB/Swiss-Prot
      Q9BZP6
      UniProtKB/TrEMBL
      A8K3T7
      Related
      ENSP00000358755.1, OTTHUMP00000012864, ENST00000369740.5, OTTHUMT00000030710
      Conserved Domains (3) summary
      cd02872
      Location:24387
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:429476
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:26365
      Glyco_18; Glyco_18 domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      111290852..111320566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006710577.3XP_006710640.1  acidic mammalian chitinase isoform X1

      See identical proteins and their annotated locations for XP_006710640.1

      UniProtKB/Swiss-Prot
      Q9BZP6
      Related
      ENSP00000390476.2, ENST00000451398.6
      Conserved Domains (3) summary
      smart00494
      Location:268315
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1204
      Glyco_18; Glyco_18 domain
      cl10447
      Location:1226
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    2. XM_017001048.1XP_016856537.1  acidic mammalian chitinase isoform X2

      UniProtKB/Swiss-Prot
      Q9BZP6
      Related
      ENSP00000391132.1, OTTHUMP00000012865, ENST00000430615.1, OTTHUMT00000030711
      Conserved Domains (2) summary
      cd02872
      Location:1279
      GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
      smart00494
      Location:321368
      ChtBD2; Chitin-binding domain type 2
    3. XM_017001047.1XP_016856536.1  acidic mammalian chitinase isoform X1

      UniProtKB/Swiss-Prot
      Q9BZP6
      Conserved Domains (3) summary
      smart00494
      Location:268315
      ChtBD2; Chitin-binding domain type 2
      smart00636
      Location:1204
      Glyco_18; Glyco_18 domain
      cl10447
      Location:1226
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      111948560..111978245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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