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    FMO2 flavin containing monooxygenase 2 [ Homo sapiens (human) ]

    Gene ID: 2327, updated on 8-Apr-2018
    Official Symbol
    FMO2provided by HGNC
    Official Full Name
    flavin containing monooxygenase 2provided by HGNC
    Primary source
    HGNC:HGNC:3770
    See related
    Ensembl:ENSG00000094963 MIM:603955; Vega:OTTHUMG00000035504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FMO1B1
    Summary
    This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Biased expression in fat (RPKM 59.7), lung (RPKM 58.7) and 8 other tissues See more
    Orthologs
    Location:
    1q24.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (171185208..171212683)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (171154388..171181822)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microRNA 1295a Neighboring gene microRNA 1295b Neighboring gene uncharacterized LOC105371611 Neighboring gene flavin containing monooxygenase 3 Neighboring gene flavin containing monooxygenase 6 pseudogene Neighboring gene flavin containing monooxygenase 1 Neighboring gene high mobility group box 1 pseudogene 11 Neighboring gene flavin containing monooxygenase 4 Neighboring gene DNA topoisomerase I pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ40826

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N,N-dimethylaniline monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    NADP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NADPH oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxygen metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    toxin metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organelle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    dimethylaniline monooxygenase [N-oxide-forming] 2
    Names
    FMO, pulmonary
    dimethylaniline oxidase 2
    flavin containing monooxygenase 2 (non-functional)
    pulmonary flavin-containing monooxygenase 2
    NP_001288276.1
    NP_001451.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301347.1NP_001288276.1  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform b

      See identical proteins and their annotated locations for NP_001288276.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate exons, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AI821378, AK098145, AK304385, AL833218, BI766311, DB224311, KF459607, R95468
      UniProtKB/TrEMBL
      B4E2Q9, Q5JPC7
      Conserved Domains (1) summary
      pfam00743
      Location:1312
      FMO-like; Flavin-binding monooxygenase-like
    2. NM_001460.4NP_001451.2  dimethylaniline monooxygenase [N-oxide-forming] 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), which represents the functional FMO2*1 allele, is the longer transcript and encodes the longer isoform (a)
      Source sequence(s)
      AI821378, AK098145, AL833218, BC005894, BI766311, DB224311, KF459607, R95468
      Consensus CDS
      CCDS1293.2
      UniProtKB/Swiss-Prot
      Q99518
      UniProtKB/TrEMBL
      Q5JPC7
      Related
      ENSP00000209929.8, OTTHUMP00000033539, ENST00000209929.9, OTTHUMT00000086216
      Conserved Domains (2) summary
      pfam00743
      Location:2532
      FMO-like; Flavin-binding monooxygenase-like
      pfam13450
      Location:758
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      171185208..171212683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_921761.3 RNA Sequence

    2. XR_001737072.2 RNA Sequence

    3. XR_426768.4 RNA Sequence

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