Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    GSTP1 glutathione S-transferase pi 1 [ Homo sapiens (human) ]

    Gene ID: 2950, updated on 16-Jul-2017
    Official Symbol
    GSTP1provided by HGNC
    Official Full Name
    glutathione S-transferase pi 1provided by HGNC
    Primary source
    HGNC:HGNC:4638
    See related
    Ensembl:ENSG00000084207 MIM:134660; Vega:OTTHUMG00000137430
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PI; DFN7; GST3; GSTP; FAEES3; HEL-S-22
    Summary
    Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. This GST family member is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q13.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (67583595..67586653)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67351066..67354125)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 associated protein 2 Neighboring gene calcium binding protein 2 Neighboring gene chromosome 11 open reading frame 72 Neighboring gene NADH:ubiquinone oxidoreductase core subunit V1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of glutathione S-transferase pi 1 (GSTP1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    JUN kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    S-nitrosoglutathione binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dinitrosyl-iron complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione binding IEA
    Inferred from Electronic Annotation
    more info
     
    glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione transferase activity TAS
    Traceable Author Statement
    more info
     
    kinase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nitric oxide binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to glucocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to insulin stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to lipopolysaccharide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to oxidative stress TAS
    Traceable Author Statement
    more info
     
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    common myeloid progenitor cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    glutathione derivative biosynthetic process TAS
    Traceable Author Statement
    more info
     
    glutathione metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    linoleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of I-kappaB kinase/NF-kappaB signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of MAPK cascade NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of acute inflammatory response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of fibroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of interleukin-1 beta production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of leukocyte proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of monocyte chemotactic protein-1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nitric-oxide synthase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smooth muscle cell chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of tumor necrosis factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of tumor necrosis factor-mediated signaling pathway IC
    Inferred by Curator
    more info
    PubMed 
    negative regulation of vascular smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    nitric oxide storage NAS
    Non-traceable Author Statement
    more info
    PubMed 
    oligodendrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of superoxide anion generation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of stress-activated MAPK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to L-ascorbic acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to amino acid IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to reactive oxygen species ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    TRAF2-GSTP1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    glutathione S-transferase P
    Names
    GST class-pi
    GSTP1-1
    deafness, X-linked 7
    epididymis secretory protein Li 22
    fatty acid ethyl ester synthase III
    NP_000843.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012075.1 RefSeqGene

      Range
      5001..8059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_723

    mRNA and Protein(s)

    1. NM_000852.3NP_000843.1  glutathione S-transferase P

      See identical proteins and their annotated locations for NP_000843.1

      Status: REVIEWED

      Source sequence(s)
      BC010915, CA946272, X15480
      Consensus CDS
      CCDS41679.1
      UniProtKB/Swiss-Prot
      P09211
      UniProtKB/TrEMBL
      V9HWE9
      Related
      ENSP00000381607.3, OTTHUMP00000174659, ENST00000398606.7, OTTHUMT00000268504
      Conserved Domains (3) summary
      PTZ00057
      Location:8196
      PTZ00057; glutathione s-transferase; Provisional
      cd03210
      Location:84210
      GST_C_Pi; C-terminal, alpha helical domain of Class Pi Glutathione S-transferases
      cd03076
      Location:376
      GST_N_Pi; GST_N family, Class Pi subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      67583595..67586653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      67234118..67237177
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center