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    Jag1 jagged 1 [ Mus musculus (house mouse) ]

    Gene ID: 16449, updated on 29-Nov-2016
    Official Symbol
    Jag1provided by MGI
    Official Full Name
    jagged 1provided by MGI
    Primary source
    MGI:MGI:1095416
    See related
    Ensembl:ENSMUSG00000027276 Vega:OTTMUSG00000015560
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Htu; Ozz; ABE2; Ser-1; Gsfabe2
    Orthologs
    Location:
    2 F3; 2 67.73 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (137081451..137116520, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (136907194..136942067, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene McKusick-Kaufman syndrome Neighboring gene SLX4 interacting protein Neighboring gene predicted gene, 38479 Neighboring gene predicted gene, 39944 Neighboring gene predicted gene 14055

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Notch binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Notch binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch signaling involved in heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Notch signaling involved in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    T cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
     
    animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    auditory receptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    auditory receptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac neural crest cell development involved in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac right ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell communication IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    distal tubule development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    endocardial cushion cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glomerular visceral epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    loop of Henle development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    morphogenesis of an epithelial sheet IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    nephron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of myeloid cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of osteoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    pulmonary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    pulmonary valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    protein jagged-1
    Names
    Serrate-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013822.5NP_038850.1  protein jagged-1 precursor

      See identical proteins and their annotated locations for NP_038850.1

      Status: VALIDATED

      Source sequence(s)
      AL713981
      Consensus CDS
      CCDS16797.1
      UniProtKB/Swiss-Prot
      Q9QXX0
      UniProtKB/TrEMBL
      Q3UVN4
      Related
      ENSMUSP00000028735, OTTMUSP00000016586, ENSMUST00000028735, OTTMUST00000036966
      Conserved Domains (5) summary
      smart00215
      Location:863930
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:629665
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:748777
      EGF; EGF-like domain
      pfam01414
      Location:167229
      DSL; Delta serrate ligand
      pfam07657
      Location:32106
      MNNL; N terminus of Notch ligand

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      137081451..137116520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239312.2XP_011237614.1  

      Conserved Domains (4) summary
      smart00215
      Location:704771
      VWC_out; von Willebrand factor (vWF) type C domain
      cd00054
      Location:470506
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00008
      Location:589618
      EGF; EGF-like domain
      pfam01414
      Location:870
      DSL; Delta serrate ligand
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