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    Ngfr nerve growth factor receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24596, updated on 15-Nov-2016
    Official Symbol
    Ngfrprovided by RGD
    Official Full Name
    nerve growth factor receptorprovided by RGD
    Primary source
    RGD:3177
    See related
    Ensembl:ENSRNOG00000005392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p75; LNGFR; p75NTR; RNNGFRR; Tnfrsf16
    Summary
    receptor that can bind NGF, BDNF, NT-3, and NT-4 [RGD, Feb 2006]
    Orthologs
    Location:
    10q26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (83389828..83408061, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (83198396..83216629, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene speckle type BTB/POZ protein Neighboring gene neurexophilin 3 Neighboring gene prohibitin Neighboring gene zinc finger protein 652

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    beta-amyloid binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    death receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nerve growth factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nerve growth factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin TRKA receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    neurotrophin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    preprotein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apoptotic signaling pathway TAS
    Traceable Author Statement
    more info
     
    axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    axon guidance ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    detection of temperature stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    hair follicle morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular protein transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell cycle TAS
    Traceable Author Statement
    more info
     
    negative regulation of dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hair follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nerve development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of odontogenesis of dentin-containing tooth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein kinase B signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synaptic transmission, cholinergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of synaptic transmission, glutamatergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucose import in response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of glucose import in response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle cell differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    skin development ISO
    Inferred from Sequence Orthology
    more info
     
    tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    coated vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    tumor necrosis factor receptor superfamily member 16
    Names
    NGF receptor
    gp80-LNGFR
    low affinity nerve growth factor receptor
    low affinity neurotrophin receptor p75NTR
    nerve growth factor receptor (TNFR superfamily, member 16)
    nerve growth factor receptor, fast
    p75 ICD

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012610.2NP_036742.2  tumor necrosis factor receptor superfamily member 16 precursor

      See identical proteins and their annotated locations for NP_036742.2

      Status: VALIDATED

      Source sequence(s)
      AABR07030380, CB725789, X05137
      UniProtKB/Swiss-Prot
      P07174
      UniProtKB/TrEMBL
      G3V6P1
      Related
      ENSRNOP00000007268, ENSRNOT00000007268
      Conserved Domains (2) summary
      cd08311
      Location:341416
      Death_p75NR; Death domain of p75 Neurotrophin Receptor
      cd13416
      Location:31189
      TNFRSF16; Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      83389828..83408061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597000.1XP_017452489.1  

    2. XM_017597001.1XP_017452490.1  

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      79287338..79305497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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