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    KRT18 keratin 18 [ Homo sapiens (human) ]

    Gene ID: 3875, updated on 26-Nov-2016
    Official Symbol
    KRT18provided by HGNC
    Official Full Name
    keratin 18provided by HGNC
    Primary source
    HGNC:HGNC:6430
    See related
    Ensembl:ENSG00000111057 HPRD:01020; MIM:148070; Vega:OTTHUMG00000169882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    K18; CK-18; CYK18
    Summary
    KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    12q13.13
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 12 NC_000012.12 (52948871..52952901)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53342655..53346690)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 78 Neighboring gene ribosomal protein L7 pseudogene 41 Neighboring gene keratin 8 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC283335 Neighboring gene tensin 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
      Caspase cascade in apoptosis, organism-specific biosystem
      Caspase cascade in apoptosis
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Keratinization, organism-specific biosystem (from REACTOME)
      Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from KEGG)
      Pathogenic Escherichia coli infection, organism-specific biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, conserved biosystem (from KEGG)
      Pathogenic Escherichia coli infection, conserved biosystemEnteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli (EHEC) are closely related pathogenic strains of Escherichia coli. The hallmark of EPEC/EHEC infections [DS:H00278 H00277] is induction o...
    • Pathogenic Escherichia coli infection, organism-specific biosystem (from WikiPathways)
      Pathogenic Escherichia coli infection, organism-specific biosystemSources: [http://www.genome.jp/kegg/pathway/hsa/hsa05130.html KEGG]
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    scaffold protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Golgi to plasma membrane CFTR protein transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    tumor necrosis factor-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell periphery IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centriolar satellite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intermediate filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    keratin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    keratin, type I cytoskeletal 18
    Names
    cell proliferation-inducing gene 46 protein
    cytokeratin 18
    keratin 18, type I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008351.1 RefSeqGene

      Range
      5189..9031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000224.2NP_000215.1  keratin, type I cytoskeletal 18

      See identical proteins and their annotated locations for NP_000215.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC000180, CD106591, X12881
      Consensus CDS
      CCDS31809.1
      UniProtKB/Swiss-Prot
      P05783
      UniProtKB/TrEMBL
      A0A024RAY2
      Related
      ENSP00000373487, OTTHUMP00000242378, ENST00000388835, OTTHUMT00000406405
      Conserved Domains (2) summary
      pfam00038
      Location:79391
      Filament; Intermediate filament protein
      cl19252
      Location:148290
      MreC; rod shape-determining protein MreC
    2. NM_199187.1NP_954657.1  keratin, type I cytoskeletal 18

      See identical proteins and their annotated locations for NP_954657.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BC000180, BG753529, CD106591, X12881
      Consensus CDS
      CCDS31809.1
      UniProtKB/Swiss-Prot
      P05783
      UniProtKB/TrEMBL
      A0A024RAY2
      Related
      ENSP00000373489, ENST00000388837
      Conserved Domains (2) summary
      pfam00038
      Location:79391
      Filament; Intermediate filament protein
      cl19252
      Location:148290
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p7 Primary Assembly

      Range
      52948871..52952901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018923.2 Alternate CHM1_1.1

      Range
      53309411..53313442
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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