Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    DRD2 dopamine receptor D2 [ Homo sapiens (human) ]

    Gene ID: 1813, updated on 15-Aug-2017
    Official Symbol
    DRD2provided by HGNC
    Official Full Name
    dopamine receptor D2provided by HGNC
    Primary source
    HGNC:HGNC:3023
    See related
    Ensembl:ENSG00000149295 MIM:126450; Vega:OTTHUMG00000167717
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    D2R; D2DR
    Summary
    This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: A frequently studied SNP, known as TaqI DRD2 (rs1800497), was originally associated with the DRD2 gene (GeneID 1813) but was later found to be located within exon 8 of the adjacent gene, ANKK1 (GeneID 255239). The location of rs1800497 is not always specified within publications. Publications may be associated with either locus or with both loci in order to point out the relationship of rs1800497 to both loci. [13 Feb 2013]
    Orthologs
    Location:
    11q23.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (113409595..113475279, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113280317..113346413, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 12 Neighboring gene ankyrin repeat and kinase domain containing 1 Neighboring gene microRNA 4301 Neighboring gene uncharacterized LOC105369501 Neighboring gene uncharacterized LOC107984390

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Myoclonic dystonia
    MedGen: C1834570 OMIM: 159900 GeneReviews: Myoclonus-Dystonia
    Compare labs

    NHGRI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    NHGRI GWA Catalog
    Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus.
    NHGRI GWA Catalog
    Genome-wide association with select biomarker traits in the Framingham Heart Study.
    NHGRI GWA Catalog
    Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
    NHGRI GWA Catalog
    Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.
    NHGRI GWA Catalog
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
    • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
      Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cocaine addiction, organism-specific biosystem (from KEGG)
      Cocaine addiction, organism-specific biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Cocaine addiction, conserved biosystem (from KEGG)
      Cocaine addiction, conserved biosystemDrug addiction is a chronic, relapsing disorder in which compulsive drug-seeking and drug-taking behavior persists despite serious negative consequences.There is strong evidence that the dopaminergic...
    • Common Pathways Underlying Drug Addiction, organism-specific biosystem (from WikiPathways)
      Common Pathways Underlying Drug Addiction, organism-specific biosystemThe pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuro...
    • Dopamine receptors, organism-specific biosystem (from REACTOME)
      Dopamine receptors, organism-specific biosystemDopamine receptors play vital roles in processes such as the control of learning, motivation, fine motor control and modulation of neuroendocrine signaling (Giralt JA and Greengard P, 2004). Abnormal...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
    • Gap junction, organism-specific biosystem (from KEGG)
      Gap junction, organism-specific biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Gap junction, conserved biosystem (from KEGG)
      Gap junction, conserved biosystemGap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels'...
    • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
      Monoamine GPCRs, organism-specific biosystem
      Monoamine GPCRs
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Nicotine Activity on Dopaminergic Neurons, organism-specific biosystem (from WikiPathways)
      Nicotine Activity on Dopaminergic Neurons, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT adrenergic receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dopamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ionotropic glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    adenohypophysis development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adult walking behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    arachidonic acid secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    associative learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    auditory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    axonogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    behavioral response to cocaine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    behavioral response to cocaine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    behavioral response to ethanol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    behavioral response to ethanol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    branching morphogenesis of a nerve ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cerebral cortex GABAergic interneuron migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    chemical synaptic transmission, postsynaptic NAS
    Non-traceable Author Statement
    more info
    PubMed 
    circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dopamine metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    grooming behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of circadian sleep/wake cycle, sleep IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of dopamine receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of dopamine secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of protein kinase B signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of protein kinase B signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of protein secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of synaptic transmission, glutamatergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of voltage-gated calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neurological system process involved in regulation of systemic arterial blood pressure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuron-neuron synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    orbitofrontal cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    peristalsis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phosphatidylinositol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    phospholipase C-activating dopamine receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pigmentation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of G-protein coupled receptor protein signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dopamine uptake involved in synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of glial cell-derived neurotrophic factor secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of growth hormone secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of neuroblast proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    prepulse inhibition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of cAMP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of dopamine secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of dopamine uptake involved in synaptic transmission IC
    Inferred by Curator
    more info
    PubMed 
    regulation of heart rate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of locomotion involved in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term neuronal synaptic plasticity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of synapse structural plasticity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of synaptic transmission, GABAergic ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    release of sequestered calcium ion into cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to amphetamine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to axon injury IEA
    Inferred from Electronic Annotation
    more info
     
    response to cocaine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    response to drug ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to histamine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    response to inactivity IEA
    Inferred from Electronic Annotation
    more info
     
    response to iron ion IEA
    Inferred from Electronic Annotation
    more info
     
    response to light stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to morphine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    response to toxic substance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sensory perception of smell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    striatum development IEA
    Inferred from Electronic Annotation
    more info
     
    synapse assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    synaptic transmission, dopaminergic IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    temperature homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    visual learning ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    ciliary membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    endocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    D(2) dopamine receptor
    Names
    dopamine D2 receptor
    dopamine receptor D2 isoform
    seven transmembrane helix receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008841.1 RefSeqGene

      Range
      5001..70685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000795.3NP_000786.1  D(2) dopamine receptor isoform long

      See identical proteins and their annotated locations for NP_000786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (long).
      Source sequence(s)
      BC021195, BF437994, DA693976, X51362
      Consensus CDS
      CCDS8361.1
      UniProtKB/Swiss-Prot
      P14416
      UniProtKB/TrEMBL
      A0A024R3C5
      Related
      ENSP00000354859.3, OTTHUMP00000236613, ENST00000362072.7, OTTHUMT00000395834
      Conserved Domains (2) summary
      pfam00001
      Location:51426
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:49233
      7tm_4; Olfactory receptor
    2. NM_016574.3NP_057658.2  D(2) dopamine receptor isoform short

      See identical proteins and their annotated locations for NP_057658.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1, but maintains the same reading frame. It encodes an isoform (short), which is 29 aa shorter than isoform long.
      Source sequence(s)
      BC021195, BF437994, DA693976, S69899, X51362
      Consensus CDS
      CCDS8362.1
      UniProtKB/Swiss-Prot
      P14416
      UniProtKB/TrEMBL
      A0A024R3I6
      Related
      ENSP00000278597.5, OTTHUMP00000236612, ENST00000346454.7, OTTHUMT00000395833
      Conserved Domains (2) summary
      pfam00001
      Location:51397
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:49233
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      113409595..113475279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017017296.1XP_016872785.1  D(2) dopamine receptor isoform X1

      UniProtKB/Swiss-Prot
      P14416
      UniProtKB/TrEMBL
      A0A024R3C5
      Related
      ENSP00000442172.1, OTTHUMP00000236615, ENST00000542968.5, OTTHUMT00000395836
      Conserved Domains (2) summary
      pfam00001
      Location:51426
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:49233
      7tm_4; Olfactory receptor

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      113163302..113228980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center