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    SLC22A6 solute carrier family 22 member 6 [ Homo sapiens (human) ]

    Gene ID: 9356, updated on 22-Apr-2017
    Official Symbol
    SLC22A6provided by HGNC
    Official Full Name
    solute carrier family 22 member 6provided by HGNC
    Primary source
    HGNC:HGNC:10970
    See related
    Ensembl:ENSG00000197901 MIM:607582; Vega:OTTHUMG00000167767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OAT1; PAHT; HOAT1; ROAT1
    Summary
    The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    11q12.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (62976597..62985023, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62744069..62752495, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369333 Neighboring gene cholinergic receptor muscarinic 1 Neighboring gene RNA, 7SL, cytoplasmic 259, pseudogene Neighboring gene solute carrier family 22 member 8 Neighboring gene pituitary tumor-transforming 1 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ55736, MGC45260

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    anion:anion antiporter activity TAS
    Traceable Author Statement
    more info
     
    chloride ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    inorganic anion exchanger activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organic anion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organic anion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    urate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    alpha-ketoglutarate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    inorganic anion transport IEA
    Inferred from Electronic Annotation
    more info
     
    organic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    organic anion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organic anion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
     
    renal tubular secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal tubular secretion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to methotrexate IEA
    Inferred from Electronic Annotation
    more info
     
    sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    urate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    solute carrier family 22 member 6
    Names
    PAH transporter
    hPAHT
    hROAT1
    organic anion transporter 1
    para-aminohippurate transporter
    renal organic anion transporter 1
    solute carrier family 22 (organic anion transporter), member 6

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004790.4NP_004781.2  solute carrier family 22 member 6 isoform a

      See identical proteins and their annotated locations for NP_004781.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also called hOAT1-1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AB009697, AI017670, DA629600
      Consensus CDS
      CCDS31591.1
      UniProtKB/Swiss-Prot
      Q4U2R8
      Related
      ENSP00000367102.3, OTTHUMP00000236797, ENST00000377871.7, OTTHUMT00000396186
      Conserved Domains (2) summary
      cd06174
      Location:135505
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11515
      2A0119; cation transport protein
    2. NM_153276.2NP_695008.1  solute carrier family 22 member 6 isoform b

      See identical proteins and their annotated locations for NP_695008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also called OAT1-2) lacks an alternate in-frame segment compared to variant 1, resulting in a shorter isoform (b) compared to isoform a.
      Source sequence(s)
      BC033682, DA629600
      Consensus CDS
      CCDS8041.1
      UniProtKB/Swiss-Prot
      Q4U2R8
      Related
      ENSP00000353597.4, OTTHUMP00000236796, ENST00000360421.8, OTTHUMT00000396184
      Conserved Domains (2) summary
      cd06174
      Location:135505
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11515
      2A0119; cation transport protein
    3. NM_153277.2NP_695009.1  solute carrier family 22 member 6 isoform c

      See identical proteins and their annotated locations for NP_695009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also called OAT1-3) lacks two alternate in-frame segments compared to variant 1, resulting in a shorter isoform (c) compared to isoform a.
      Source sequence(s)
      AI017670, AJ251529, DA628191, DA629600, DB320467
      Consensus CDS
      CCDS44632.1
      UniProtKB/Swiss-Prot
      Q4U2R8
      Related
      ENSP00000396401.2, OTTHUMP00000236798, ENST00000458333.6, OTTHUMT00000396187
      Conserved Domains (2) summary
      cd06174
      Location:135456
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11471
      2A0119; cation transport protein
    4. NM_153278.2NP_695010.1  solute carrier family 22 member 6 isoform d

      See identical proteins and their annotated locations for NP_695010.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4, also called OAT1-4) lacks an alternate in-frame segment compared to variant 1, resulting in a shorter isoform (d) compared to isoform a.
      Source sequence(s)
      AB009697, AI017670, AJ271205, DA628191, DA629600
      Consensus CDS
      CCDS44631.1
      UniProtKB/Swiss-Prot
      Q4U2R8
      Related
      ENSP00000404441.2, OTTHUMP00000236799, ENST00000421062.2, OTTHUMT00000396188
      Conserved Domains (2) summary
      cd06174
      Location:135456
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11471
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      62976597..62985023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018562.1XP_016874051.1  solute carrier family 22 member 6 isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      62626827..62635253 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_153279.1: Suppressed sequence

      Description
      NM_153279.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Support Center