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    ESRRG estrogen related receptor gamma [ Homo sapiens (human) ]

    Gene ID: 2104, updated on 9-Jul-2017
    Official Symbol
    ESRRGprovided by HGNC
    Official Full Name
    estrogen related receptor gammaprovided by HGNC
    Primary source
    HGNC:HGNC:3474
    See related
    Ensembl:ENSG00000196482 MIM:602969; Vega:OTTHUMG00000037025
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERR3; NR3B3; ERRgamma
    Summary
    This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
    Orthologs
    Location:
    1q41
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (216503246..217137757, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (216676588..217311097, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene uncharacterized LOC105372918 Neighboring gene mitochondrial ribosomal protein S18B pseudogene 1 Neighboring gene uncharacterized LOC107985596 Neighboring gene uncharacterized LOC107985461 Neighboring gene uncharacterized LOC105372920

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
    NHGRI GWA Catalog
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    NHGRI GWA Catalog
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    NHGRI GWA Catalog
    Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
    NHGRI GWA Catalog
    Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
    NHGRI GWA Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    NHGRI GWA Catalog
    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
    NHGRI GWA Catalog
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
      Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ16023, KIAA0832, DKFZp781L1617

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    AF-2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoic acid receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription, DNA-templated ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    estrogen-related receptor gamma
    Names
    ERR gamma-2
    estrogen receptor-related protein 3
    nuclear receptor subfamily 3 group B member 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029784.1 RefSeqGene

      Range
      5001..639510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134285.2NP_001127757.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001127757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, BX647076
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Related
      ENSP00000355907.2, OTTHUMP00000035095, ENST00000366940.6, OTTHUMT00000089921
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    2. NM_001243505.1NP_001230434.1  estrogen-related receptor gamma isoform 3

      See identical proteins and their annotated locations for NP_001230434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three exons from the 5' end but has alternate three 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020639, BM723962, BU752915
      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (1) summary
      cd06946
      Location:1205
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
    3. NM_001243506.1NP_001230435.1  estrogen-related receptor gamma isoform 4

      See identical proteins and their annotated locations for NP_001230435.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two exons from the 5' end but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020639, AK298851, BP349857, BU752915
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      B7Z5E9
      Conserved Domains (2) summary
      cd06946
      Location:52271
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:133
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    4. NM_001243507.1NP_001230436.1  estrogen-related receptor gamma isoform 5

      See identical proteins and their annotated locations for NP_001230436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks a 5' exon and an internal in-frame exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (5, also known as ERRgamma3) is shorter at the N-terminus and lacks an internal segment corresponding to the second zinc finger motif of the DNA binding domain (PMID:16460929), compared to isoform 1.
      Source sequence(s)
      AB020639, AB362218, AK131193, BU752915, DB220304
      Consensus CDS
      CCDS58060.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      C0SQ93
      Related
      ENSP00000418629.1, OTTHUMP00000216806, ENST00000463665.5, OTTHUMT00000357845
      Conserved Domains (2) summary
      cd06946
      Location:175394
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:99156
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
    5. NM_001243509.1NP_001230438.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230438.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, BU752915, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000417374.1, OTTHUMP00000216807, ENST00000493748.5, OTTHUMT00000357846
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    6. NM_001243510.2NP_001230439.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230439.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AY388457, BU752915, BX647076, DA293919
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Related
      ENSP00000419594.1, OTTHUMP00000216805, ENST00000493603.5, OTTHUMT00000357844
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    7. NM_001243511.2NP_001230440.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230440.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AY388460, BU752915, BX647076, DA293919
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    8. NM_001243512.1NP_001230441.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230441.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks the 5' exon but has more than three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AK131193, AY388458, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000419155.1, OTTHUMP00000216808, ENST00000487276.5, OTTHUMT00000357847
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    9. NM_001243513.1NP_001230442.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230442.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks the 5' exon but has more than two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AY388459, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000355905.2, OTTHUMP00000035116, ENST00000366938.6, OTTHUMT00000089960
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    10. NM_001243514.1NP_001230443.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks the 5' exon but has an alternate 5' exon and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AC096635, AY388461, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Related
      ENSP00000353108.3, OTTHUMP00000035126, ENST00000360012.7, OTTHUMT00000089974
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    11. NM_001243515.1NP_001230444.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230444.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) has two additional exons in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AK290945, BU752915, DA720944, DA722064
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    12. NM_001243518.1NP_001230447.1  estrogen-related receptor gamma isoform 6

      See identical proteins and their annotated locations for NP_001230447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) has an additional exon in the 5' region, which includes an AUG start codon, and an additional segment in the middle region, compared to variant 1. The resulting isoform (6) has a longer and distinct N-terminus and an additional internal segment, compared to isoform 1.
      Source sequence(s)
      AB020639, BC064700, BU752915, DA720944
      Consensus CDS
      CCDS58061.1
      UniProtKB/Swiss-Prot
      P62508
      Related
      ENSP00000355904.1, OTTHUMP00000035075, ENST00000366937.5, OTTHUMT00000089881
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    13. NM_001243519.1NP_001230448.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) has an additional segment in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BC008218, BU752915, DA720944
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Related
      ENSP00000375761.4, ENST00000391890.7
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    14. NM_001350122.1NP_001337051.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AL603752, BU752915, CA397450, DA215341, DA293919, DB220304
    15. NM_001350123.1NP_001337052.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BP349857, BU752915, CA397450, DB220304
    16. NM_001350124.1NP_001337053.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AL603752, BU752915, BX647076, CA397450, DA215341
    17. NM_001350125.1NP_001337054.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, CA397450, DA096417, DB220304
    18. NM_001438.3NP_001429.2  estrogen-related receptor gamma isoform 1

      See identical proteins and their annotated locations for NP_001429.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB020639, BU752915, DA720944
      Consensus CDS
      CCDS41468.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R5
      Related
      ENSP00000386171.3, OTTHUMP00000035076, ENST00000408911.7, OTTHUMT00000089882
      Conserved Domains (2) summary
      cd06946
      Location:237456
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:122218
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    19. NM_206594.2NP_996317.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_996317.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BP349857, BU752915, CA397450
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Related
      ENSP00000355225.3, ENST00000361525.7
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    20. NM_206595.2NP_996318.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_996318.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks the 5' exon but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AK291028, BP349857, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Related
      ENSP00000352077.2, OTTHUMP00000035092, ENST00000359162.6, OTTHUMT00000089913
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      216503246..217137757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000643.1XP_016856132.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    2. XM_017000625.1XP_016856114.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    3. XM_017000647.1XP_016856136.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    4. XM_017000649.1XP_016856138.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    5. XM_017000639.1XP_016856128.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    6. XM_017000633.1XP_016856122.1  estrogen-related receptor gamma isoform X8

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    7. XM_017000648.1XP_016856137.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    8. XM_017000642.1XP_016856131.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    9. XM_017000622.1XP_016856111.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    10. XM_011509277.1XP_011507579.1  estrogen-related receptor gamma isoform X8

      See identical proteins and their annotated locations for XP_011507579.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    11. XM_017000644.1XP_016856133.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    12. XM_011509275.1XP_011507577.1  estrogen-related receptor gamma isoform X8

      See identical proteins and their annotated locations for XP_011507577.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    13. XM_017000624.1XP_016856113.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    14. XM_011509265.2XP_011507567.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    15. XM_017000621.1XP_016856110.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    16. XM_017000646.1XP_016856135.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    17. XM_017000640.1XP_016856129.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    18. XM_017000637.1XP_016856126.1  estrogen-related receptor gamma isoform X8

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    19. XM_017000645.1XP_016856134.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    20. XM_011509278.1XP_011507580.1  estrogen-related receptor gamma isoform X8

      See identical proteins and their annotated locations for XP_011507580.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    21. XM_011509274.1XP_011507576.1  estrogen-related receptor gamma isoform X8

      See identical proteins and their annotated locations for XP_011507576.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    22. XM_017000634.1XP_016856123.1  estrogen-related receptor gamma isoform X8

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    23. XM_017000638.1XP_016856127.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    24. XM_017000631.1XP_016856120.1  estrogen-related receptor gamma isoform X8

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    25. XM_017000632.1XP_016856121.1  estrogen-related receptor gamma isoform X8

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    26. XM_011509266.2XP_011507568.1  estrogen-related receptor gamma isoform X2

      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    27. XM_017000636.1XP_016856125.1  estrogen-related receptor gamma isoform X8

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    28. XM_017000623.1XP_016856112.1  estrogen-related receptor gamma isoform X1

      Conserved Domains (2) summary
      cd06946
      Location:256475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    29. XM_011509270.1XP_011507572.1  estrogen-related receptor gamma isoform X4

      See identical proteins and their annotated locations for XP_011507572.1

      Conserved Domains (2) summary
      cd06946
      Location:244463
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:122218
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    30. XM_011509268.2XP_011507570.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507570.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    31. XM_011509271.2XP_011507573.1  estrogen-related receptor gamma isoform X7

      See identical proteins and their annotated locations for XP_011507573.1

      Conserved Domains (2) summary
      cd06946
      Location:226445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:104200
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    32. XM_011509280.2XP_011507582.1  estrogen-related receptor gamma isoform X8

      See identical proteins and their annotated locations for XP_011507582.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    33. XM_017000627.1XP_016856116.1  estrogen-related receptor gamma isoform X5

    34. XM_011509276.1XP_011507578.1  estrogen-related receptor gamma isoform X8

      See identical proteins and their annotated locations for XP_011507578.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    35. XM_017000641.1XP_016856130.1  estrogen-related receptor gamma isoform X9

      UniProtKB/Swiss-Prot
      P62508
      UniProtKB/TrEMBL
      F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    36. XM_011509279.1XP_011507581.1  estrogen-related receptor gamma isoform X8

      See identical proteins and their annotated locations for XP_011507581.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    37. XM_011509267.1XP_011507569.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507569.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    38. XM_017000630.1XP_016856119.1  estrogen-related receptor gamma isoform X7

      Conserved Domains (2) summary
      cd06946
      Location:226445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:104200
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    39. XM_017000635.1XP_016856124.1  estrogen-related receptor gamma isoform X8

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:221440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    40. XM_017000628.1XP_016856117.1  estrogen-related receptor gamma isoform X6

      Conserved Domains (2) summary
      cd06946
      Location:240459
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:118214
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    41. XM_011509269.2XP_011507571.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507571.1

      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (2) summary
      cd06946
      Location:249468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers
    42. XM_017000626.1XP_016856115.1  estrogen-related receptor gamma isoform X5

    43. XM_017000629.1XP_016856118.1  estrogen-related receptor gamma isoform X7

      Conserved Domains (2) summary
      cd06946
      Location:226445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:104200
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      217949719..218583931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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