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    Parp1 poly (ADP-ribose) polymerase family, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 11545, updated on 8-Oct-2017
    Official Symbol
    Parp1provided by MGI
    Official Full Name
    poly (ADP-ribose) polymerase family, member 1provided by MGI
    Primary source
    MGI:MGI:1340806
    See related
    Ensembl:ENSMUSG00000026496 Vega:OTTMUSG00000050450
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PARP; PPOL; ARTD1; Adprp; Adprt1; C80510; parp-1; sPARP-1; AI893648; 5830444G22Rik
    Orthologs
    Location:
    1 H4; 1 84.44 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (180568975..180601254)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (182499106..182531385)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene mechanosensory transduction mediator Neighboring gene predicted gene, 31986 Neighboring gene microRNA 6904 Neighboring gene lin-9 homolog (C. elegans) Neighboring gene Mix1 homeobox-like 1 (Xenopus laevis)

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    NAD+ ADP-ribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein ADP-ribosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ADP-ribosylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein N-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    ATP generation from poly-ADP-D-ribose ISO
    Inferred from Sequence Orthology
    more info
     
    DNA damage response, detection of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    DNA ligation involved in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    DNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to amyloid-beta ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to superoxide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
     
    lagging strand elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    mitochondrial DNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrial DNA repair ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-17 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of telomere maintenance via telomere lengthening IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-serine ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of SMAD protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myofibroblast differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autoprocessing ISO
    Inferred from Sequence Orthology
    more info
     
    protein modification process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein poly-ADP-ribosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein poly-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of SMAD protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of growth rate IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of single strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction involved in regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    poly [ADP-ribose] polymerase 1
    Names
    ADP-ribosyltransferase (NAD+, poly (ADP-ribose) polymerase) 1
    ADP-ribosyltransferase diphtheria toxin-like 1
    ADPRT 1
    NAD(+) ADP-ribosyltransferase 1
    msPARP
    poly(ADP-ribose) polymerase
    poly[ADP-ribose] synthase 1
    poly[ADP-ribose] synthetase 1
    NP_031441.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007415.2NP_031441.2  poly [ADP-ribose] polymerase 1

      See identical proteins and their annotated locations for NP_031441.2

      Status: PROVISIONAL

      Source sequence(s)
      BC012041
      Consensus CDS
      CCDS15569.1
      UniProtKB/TrEMBL
      Q921K2
      Related
      ENSMUSP00000027777.6, OTTMUSP00000068942, ENSMUST00000027777.11, OTTMUST00000128005
      Conserved Domains (6) summary
      cd08001
      Location:543645
      WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins
      PLN03123
      Location:91010
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      cd01437
      Location:6621006
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00533
      Location:389462
      BRCT; BRCA1 C Terminus (BRCT) domain
      pfam00645
      Location:1287
      zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
      pfam08063
      Location:281332
      PADR1; PADR1 (NUC008) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      180568975..180601254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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