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    NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit [ Homo sapiens (human) ]

    Gene ID: 8260, updated on 8-Oct-2017
    Official Symbol
    NAA10provided by HGNC
    Official Full Name
    N(alpha)-acetyltransferase 10, NatA catalytic subunitprovided by HGNC
    Primary source
    HGNC:HGNC:18704
    See related
    Ensembl:ENSG00000102030 MIM:300013; Vega:OTTHUMG00000024225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1
    Summary
    N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
    Orthologs
    Location:
    Xq28
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) X NC_000023.11 (153929827..153935154, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153195280..153200607, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene arginine vasopressin receptor 2 Neighboring gene Rho GTPase activating protein 4 Neighboring gene renin binding protein Neighboring gene host cell factor C1 Neighboring gene HCFC1 antisense RNA 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ78896, MGC71248

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acetyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to peptide alpha-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptide-glutamate-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptide-serine-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to ribosome binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA packaging TAS
    Traceable Author Statement
    more info
    PubMed 
    N-terminal peptidyl-glutamic acid acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    N-terminal peptidyl-serine acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    N-terminal protein amino acid acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    internal protein amino acid acetylation TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    NatA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosolic ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular IDA
    Inferred from Direct Assay
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    N-alpha-acetyltransferase 10
    Names
    ARD1 homolog A, N-acetyltransferase
    N-acetyltransferase ARD1, human homolog of
    N-terminal acetyltransferase complex ARD1 subunit homolog A
    natA catalytic subunit Naa10
    NP_001243048.1
    NP_001243049.1
    NP_003482.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031987.1 RefSeqGene

      Range
      5001..10328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256119.1NP_001243048.1  N-alpha-acetyltransferase 10 isoform 2

      See identical proteins and their annotated locations for NP_001243048.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AY183135, CA313208, CR979270
      Consensus CDS
      CCDS59179.1
      UniProtKB/Swiss-Prot
      P41227
      Related
      ENSP00000359026.1, OTTHUMP00000026002, ENST00000370009.5, OTTHUMT00000061109
      Conserved Domains (2) summary
      COG0456
      Location:1134
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47113
      Acetyltransf_1; Acetyltransferase (GNAT) family
    2. NM_001256120.1NP_001243049.1  N-alpha-acetyltransferase 10 isoform 3

      See identical proteins and their annotated locations for NP_001243049.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AK315997, AY183135, BI192945, CA313208, CR979270
      UniProtKB/TrEMBL
      B7Z9N2
      Conserved Domains (2) summary
      COG0456
      Location:1143
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47116
      Acetyltransf_1; Acetyltransferase (GNAT) family
    3. NM_003491.3NP_003482.1  N-alpha-acetyltransferase 10 isoform 1

      See identical proteins and their annotated locations for NP_003482.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BC000308, CA313208, CR979270
      Consensus CDS
      CCDS14737.1
      UniProtKB/Swiss-Prot
      P41227
      Related
      ENSP00000417763.1, OTTHUMP00000026001, ENST00000464845.5, OTTHUMT00000061108
      Conserved Domains (1) summary
      COG0456
      Location:1149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p7 Primary Assembly

      Range
      153929827..153935154 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018934.2 Alternate CHM1_1.1

      Range
      153069735..153075062 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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