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    Rbpj recombination signal binding protein for immunoglobulin kappa J region [ Mus musculus (house mouse) ]

    Gene ID: 19664, updated on 13-Dec-2017
    Official Symbol
    Rbpjprovided by MGI
    Official Full Name
    recombination signal binding protein for immunoglobulin kappa J regionprovided by MGI
    Primary source
    MGI:MGI:96522
    See related
    Ensembl:ENSMUSG00000039191 Vega:OTTMUSG00000054613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CBF1; RBP-J; RBPjk; Igkjrb; Rbpsuh; Igkrsbp; AI843960; RBP-Jkappa; RBP-J kappa
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 12.9), CNS E11.5 (RPKM 12.5) and 28 other tissues See more
    Orthologs
    Location:
    5 C1; 5 29.37 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (53466115..53657445)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (53947018..54048684)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40303 Neighboring gene small integral membrane protein 20 Neighboring gene predicted gene, 40304 Neighboring gene cholecystokinin A receptor Neighboring gene TBC1 domain family, member 19

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    repressing transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Clara cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Notch signaling pathway involved in arterial endothelial cell fate commitment IC
    Inferred by Curator
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    arterial endothelial cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrioventricular canal development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    auditory receptor cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel endothelial cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    blood vessel lumenization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac left ventricle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of heart left/right asymmetry TAS
    Traceable Author Statement
    more info
    PubMed 
    dorsal aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial to mesenchymal transition involved in endocardial cushion formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping TAS
    Traceable Author Statement
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response to antigenic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-4 secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    keratinocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid dendritic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pituitary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ERBB signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Notch signaling pathway involved in heart induction TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation involved in heart morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ephrin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription of Notch receptor target IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription of Notch receptor target ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cell adhesion involved in heart morphogenesis IC
    Inferred by Curator
    more info
    PubMed 
    regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of timing of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    sebaceous gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    secondary heart field specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    secondary heart field specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somitogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    ventricular trabecula myocardium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    MAML1-RBP-Jkappa- ICN1 complex ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IC
    Inferred by Curator
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional repressor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    recombining binding protein suppressor of hairless
    Names
    J-kappa recombination signal binding protein
    Jkappa recombination signal binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080927.2NP_001074396.1  recombining binding protein suppressor of hairless isoform 2

      See identical proteins and their annotated locations for NP_001074396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084054, AK028363, AK080359, AK132145, BY716845
      Consensus CDS
      CCDS51504.1
      UniProtKB/Swiss-Prot
      P31266
      UniProtKB/TrEMBL
      Q3UM17
      Related
      ENSMUSP00000109496.1, OTTMUSP00000071653, ENSMUST00000113865.4, OTTMUST00000135392
      Conserved Domains (3) summary
      cd01176
      Location:337433
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:166315
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:35164
      LAG1-DNAbind; LAG1, DNA binding
    2. NM_001080928.1NP_001074397.1  recombining binding protein suppressor of hairless isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC084054, AK028363, AK132145, BB839243, CD540070
      Consensus CDS
      CCDS51503.1
      UniProtKB/TrEMBL
      E9Q7W0
      Related
      ENSMUSP00000084618.2, OTTMUSP00000071649, ENSMUST00000087360.8, OTTMUST00000135386
      Conserved Domains (3) summary
      cd01176
      Location:335431
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:164313
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:33162
      LAG1-DNAbind; LAG1, DNA binding
    3. NM_001277116.1NP_001264045.1  recombining binding protein suppressor of hairless isoform 4

      See identical proteins and their annotated locations for NP_001264045.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK028363, AK132145, AK152746
      Consensus CDS
      CCDS80283.1
      UniProtKB/TrEMBL
      A0A0J9YTV5
      Related
      ENSMUSP00000143866.1, OTTMUSP00000071652, ENSMUST00000201912.3, OTTMUST00000135389
      Conserved Domains (3) summary
      cd01176
      Location:357453
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:186335
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:55184
      LAG1-DNAbind; LAG1, DNA binding
    4. NM_009035.5NP_033061.3  recombining binding protein suppressor of hairless isoform 1

      See identical proteins and their annotated locations for NP_033061.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK028363, AK132145, AK152746, BY155397
      Consensus CDS
      CCDS19292.1
      UniProtKB/Swiss-Prot
      P31266
      Related
      ENSMUSP00000040694.6, OTTMUSP00000071650, ENSMUST00000037618.12, OTTMUST00000135387
      Conserved Domains (3) summary
      cd01176
      Location:376472
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:205354
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:74203
      LAG1-DNAbind; LAG1, DNA binding

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      53466115..53657445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503797.3XP_006503860.1  recombining binding protein suppressor of hairless isoform X2

      Conserved Domains (3) summary
      cd01176
      Location:341437
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:170319
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:39168
      LAG1-DNAbind; LAG1, DNA binding
    2. XM_017320743.1XP_017176232.1  recombining binding protein suppressor of hairless isoform X5

    3. XM_006503799.2XP_006503862.1  recombining binding protein suppressor of hairless isoform X3

      See identical proteins and their annotated locations for XP_006503862.1

      UniProtKB/TrEMBL
      Q3U6F1
      Related
      ENSMUSP00000143846.1, OTTMUSP00000071655, ENSMUST00000201883.3, OTTMUST00000135394
      Conserved Domains (3) summary
      cd01176
      Location:315411
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:144293
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:13142
      LAG1-DNAbind; LAG1, DNA binding
    4. XM_017320742.1XP_017176231.1  recombining binding protein suppressor of hairless isoform X4

    5. XM_006503796.3XP_006503859.1  recombining binding protein suppressor of hairless isoform X1

      Conserved Domains (3) summary
      cd01176
      Location:379475
      IPT_RBP-Jkappa; IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known ...
      pfam09270
      Location:208357
      BTD; Beta-trefoil DNA-binding domain
      pfam09271
      Location:77206
      LAG1-DNAbind; LAG1, DNA binding
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