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    Ptpdc1 protein tyrosine phosphatase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 218232, updated on 16-May-2017
    Official Symbol
    Ptpdc1provided by MGI
    Official Full Name
    protein tyrosine phosphatase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2145430
    See related
    Ensembl:ENSMUSG00000038042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naa-1; Ptpcd1; AI843923; AW456874
    Summary
    The protein encoded by this gene is a centrosomal mitotic phosphatase. This protein has been implicated in centrosomal duplication and cytokinesis. In addition, knockdown of expression levels in non-cycling cells results in extra long cilia, suggesting that this protein may function in regulating cilia length independent of a function in cell cycle control. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
    Orthologs
    Location:
    13; 13 A5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (48577869..48625672, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (48673241..48720942, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene microRNA let7f-1 Neighboring gene microRNA let7a-1 Neighboring gene uncharacterized LOC108168081 Neighboring gene predicted gene, 36606 Neighboring gene BarH-like homeobox 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphoprotein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein tyrosine/serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cell projection organization IEA
    Inferred from Electronic Annotation
    more info
     
    cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    protein tyrosine phosphatase domain-containing protein 1
    NP_001288710.1
    NP_997115.1
    XP_006516985.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301781.1NP_001288710.1  protein tyrosine phosphatase domain-containing protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI843923, AK030415, AK132781, CJ169499
      UniProtKB/Swiss-Prot
      Q6NZK8
      Conserved Domains (1) summary
      smart00404
      Location:215296
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    2. NM_207232.2NP_997115.1  protein tyrosine phosphatase domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_997115.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AI843923, AK030415, CJ169499
      Consensus CDS
      CCDS26495.1
      UniProtKB/Swiss-Prot
      Q6NZK8
      Related
      ENSMUSP00000047374.9, ENSMUST00000035824.9
      Conserved Domains (1) summary
      smart00404
      Location:154235
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      48577869..48625672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516922.2XP_006516985.1  protein tyrosine phosphatase domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      smart00404
      Location:202283
      PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
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