Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Git1 G protein-coupled receptor kinase-interactor 1 [ Mus musculus (house mouse) ]

    Gene ID: 216963, updated on 4-Jun-2017
    Official Symbol
    Git1provided by MGI
    Official Full Name
    G protein-coupled receptor kinase-interactor 1provided by MGI
    Primary source
    MGI:MGI:1927140
    See related
    Ensembl:ENSMUSG00000011877 Vega:OTTMUSG00000008178
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cat-1; p95Cat
    Orthologs
    Location:
    11; 11 B5
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (77493412..77507775)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (77306914..77321276)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene coronin 6 Neighboring gene ankyrin repeat domain 13b Neighboring gene RIKEN cDNA 2210008F06 gene Neighboring gene transformation related protein 53 inducible protein 13 Neighboring gene abhydrolase domain containing 15 Neighboring gene TAO kinase 1 Neighboring gene eukaryotic translation initiation factor 2, subunit 1 alpha pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    immunological synapse formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of ARF protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G-protein coupled receptor protein signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    synapse ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ARF GTPase-activating protein GIT1
    Names
    ARF GAP GIT1
    G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
    GRK-interacting protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004144.1NP_001004144.1  ARF GTPase-activating protein GIT1

      See identical proteins and their annotated locations for NP_001004144.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079870
      Consensus CDS
      CCDS25080.1
      UniProtKB/Swiss-Prot
      Q68FF6
      Related
      ENSMUSP00000037210.3, OTTMUSP00000008532, ENSMUST00000037285.9, OTTMUST00000018574
      Conserved Domains (7) summary
      smart00105
      Location:3124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:123220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:337365
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:649763
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:418482
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      77493412..77507775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532949.2XP_006533012.1  ARF GTPase-activating protein GIT1 isoform X1

      UniProtKB/TrEMBL
      Q5F258
      Related
      ENSMUSP00000098375.3, OTTMUSP00000008533, ENSMUST00000100812.3, OTTMUST00000018577
      Conserved Domains (7) summary
      smart00105
      Location:3124
      ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF
      cd00204
      Location:123220
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam08518
      Location:328356
      GIT_SHD; Spa2 homology domain (SHD) of GIT
      pfam12205
      Location:640754
      GIT1_C; G protein-coupled receptor kinase-interacting protein 1 C term
      pfam12796
      Location:137229
      Ank_2; Ankyrin repeats (3 copies)
      pfam16559
      Location:409473
      GIT_CC; GIT coiled-coil Rho guanine nucleotide exchange factor
      sd00045
      Location:137165
      ANK; ANK repeat [structural motif]
    Support Center