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    PLC1 phosphatidylinositol phospholipase C [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855860, updated on 5-Jun-2017
    Gene symbol
    PLC1
    Gene description
    phosphatidylinositol phospholipase C
    Primary source
    SGD:S000006189
    Locus tag
    YPL268W
    Gene type
    protein coding
    RNA name
    phosphatidylinositol phospholipase C
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See PLC1 in Map Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (35236..37845)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette permease MDL2 Neighboring gene Kar9p Neighboring gene Acm1p Neighboring gene putative dimethyladenosine transferase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol phospholipase C activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    inositol phosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phospholipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction involved in filamentous growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    signal transduction involved in filamentous growth IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed nuclear chromosome kinetochore IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Names
    phosphatidylinositol phospholipase C
    NP_015055.1
    • Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      35236..37845
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184082.1NP_015055.1  TPA: phosphatidylinositol phospholipase C [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015055.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P32383
      Conserved Domains (4) summary
      cd00275
      Location:732868
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08598
      Location:379688
      PI-PLC1c_yeast; Catalytic domain of putative yeast phosphatidylinositide-specific phospholipases C
      PLN02952
      Location:284856
      PLN02952; phosphoinositide phospholipase C
      cd13360
      Location:124224
      PH_PLC_fungal; Fungal Phospholipase C (PLC) pleckstrin homology (PH) domain
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