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    Dbn1 drebrin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81653, updated on 9-Jul-2017
    Official Symbol
    Dbn1provided by RGD
    Official Full Name
    drebrin 1provided by RGD
    Primary source
    RGD:70885
    See related
    Ensembl:ENSRNOG00000014170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    may play a role in neurite outgrowth [RGD, Feb 2006]
    Orthologs
    Location:
    17p14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9679511..9693878)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (11788527..11802863)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348506 Neighboring gene docking protein 3 Neighboring gene PDZ and LIM domain 7 Neighboring gene proline rich 7 (synaptic) Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene uncharacterized LOC102550356

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cadherin binding IEA
    Inferred from Electronic Annotation
    more info
     
    cadherin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    profilin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament organization IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    brain development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cell communication by chemical coupling IEA
    Inferred from Electronic Annotation
    more info
     
    cell communication by chemical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    cell communication by electrical coupling IEA
    Inferred from Electronic Annotation
    more info
     
    cell communication by electrical coupling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to X-ray IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    generation of neurons IEA
    Inferred from Electronic Annotation
    more info
     
    generation of neurons ISO
    Inferred from Sequence Orthology
    more info
     
    lung alveolus development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    maintenance of protein location in cell IEA
    Inferred from Electronic Annotation
    more info
     
    maintenance of protein location in cell ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of inhibitory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of actin-dependent ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of locomotion involved in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of muscle filament sliding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    neural precursor cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell-substrate adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prepulse inhibition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynaptic density protein 95 clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    spermatogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    asymmetric synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axonal spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gap junction IEA
    Inferred from Electronic Annotation
    more info
     
    gap junction ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    neuron spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density of dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    drebrin
    Names
    developmentally-regulated brain protein
    drebrin E

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031024.1NP_112286.1  drebrin

      See identical proteins and their annotated locations for NP_112286.1

      Status: PROVISIONAL

      Source sequence(s)
      X59267
      UniProtKB/Swiss-Prot
      Q07266
      Conserved Domains (1) summary
      cd11281
      Location:4139
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      9679511..9693878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253655.3XP_006253717.1  drebrin isoform X1

      See identical proteins and their annotated locations for XP_006253717.1

      UniProtKB/TrEMBL
      A0A0H2UHL9
      Related
      ENSRNOP00000019569.4, ENSRNOT00000019569.7
      Conserved Domains (1) summary
      cd11281
      Location:4139
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    2. XM_006253656.3XP_006253718.1  drebrin isoform X2

      See identical proteins and their annotated locations for XP_006253718.1

      UniProtKB/TrEMBL
      C6L8E0
      Related
      ENSRNOP00000019393.2, ENSRNOT00000019393.4
      Conserved Domains (1) summary
      cd11281
      Location:4139
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    3. XM_006253657.3XP_006253719.1  drebrin isoform X3

      See identical proteins and their annotated locations for XP_006253719.1

      UniProtKB/Swiss-Prot
      Q07266
      Conserved Domains (1) summary
      cd11281
      Location:4139
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)
    4. XM_008771507.2XP_008769729.1  drebrin isoform X4

      Conserved Domains (1) summary
      cd11281
      Location:26135
      ADF_drebrin_like; ADF homology domain of drebrin and actin-binding protein 1 (abp1)

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      9229222..9243194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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