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    RTT109 H3 histone acetyltransferase RTT109 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 850658, updated on 15-Nov-2016
    Gene symbol
    RTT109
    Gene description
    H3 histone acetyltransferase RTT109
    Primary source
    SGD:S000003925
    Locus tag
    YLL002W
    Gene type
    protein coding
    RNA name
    H3 histone acetyltransferase RTT109
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAT11; KIM2; REM50
    See RTT109 in Map Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (146291..147601)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 3 Neighboring gene Sfi1p Neighboring gene dynamin-related GTPase DNM1 Neighboring gene hypothetical protein

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    H3 histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    H3 histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    H3 histone acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    H3 histone acetyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetyltransferase activity (H3-K56 specific) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin silencing at centromere IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone H3 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone H3-K56 acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    histone acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone acetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of rDNA IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transposition, RNA-mediated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to stress IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription from RNA polymerase II promoter in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    H3 histone acetyltransferase RTT109
    NP_013099.1
    • Histone acetyltransferase; critical for cell survival in presence of DNA damage during S phase; acetylates H3K56, H3K9; H3K56 acetylation activity required for expression homeostasis, buffering of mRNA synthesis rate against changes in gene dosage during S phase; involved in non-homologous end joining and regulation of Ty1 transposition; prevents hyper-amplification of rDNA; interacts physically with Vps75p

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      146291..147601
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181822.1NP_013099.1  TPA: H3 histone acetyltransferase RTT109 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_013099.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q07794
      Conserved Domains (1) summary
      COG5087
      Location:3432
      RTT109; Uncharacterized conserved protein [Function unknown]
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