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    Gpx1 glutathione peroxidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14775, updated on 5-Nov-2017
    Official Symbol
    Gpx1provided by MGI
    Official Full Name
    glutathione peroxidase 1provided by MGI
    Primary source
    MGI:MGI:104887
    See related
    Ensembl:ENSMUSG00000063856 Vega:OTTMUSG00000050754
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gpx; CGPx; GPx-1; GSHPx-1; AI195024; AL033363
    Summary
    The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Knockout mice lacking this gene are highly sensitive to oxidants, and develop mature cataracts due to damage to the eye lens nucleus. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
    Orthologs
    Location:
    9 F2; 9 59.24 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (108339080..108340342)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (108241607..108242671)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene T cell leukemia translocation altered gene Neighboring gene ras homolog family member A Neighboring gene ubiquitin specific peptidase 4 (proto-oncogene) Neighboring gene ribosomal protein S2, pseudogene 11 Neighboring gene RIKEN cDNA 1700102P08 gene Neighboring gene coiled-coil domain containing 36

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutathione peroxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutathione peroxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    UV protection ISO
    Inferred from Sequence Orthology
    more info
     
    angiogenesis involved in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    endothelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutathione metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart contraction ISO
    Inferred from Sequence Orthology
    more info
     
    hydrogen peroxide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hydrogen peroxide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    interaction with symbiont IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inflammatory response to antigenic stimulus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mammary gland epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to gamma radiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    response to hydroperoxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to reactive oxygen species IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to selenium ion ISO
    Inferred from Sequence Orthology
    more info
     
    response to symbiotic bacterium IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    temperature homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    triglyceride metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with Lewy body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glutathione peroxidase 1
    Names
    cellular glutathione peroxidase
    selenium-dependent glutathione peroxidase 1
    NP_032186.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001329527.1NP_001316456.1  glutathione peroxidase 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the 3' terminal exon compared to variant 1. The resulting isoform (2) is 1 amino acid shorter than isoform 1.
      Source sequence(s)
      BC086649, BY113381, CK628430
      UniProtKB/Swiss-Prot
      P11352
    2. NM_001329528.1NP_001316457.1  glutathione peroxidase 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) is alternatively spliced in the 5' coding region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The resulting isoform (3) has a shorter N-terminus lacking the selenocysteine residue compared to isoform 1.
      Source sequence(s)
      AW611014, BC086649, CK628430
      UniProtKB/Swiss-Prot
      P11352
      UniProtKB/TrEMBL
      A0A0A6YVV2
    3. NM_008160.6NP_032186.2  glutathione peroxidase 1 isoform 1

      See identical proteins and their annotated locations for NP_032186.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC086649, CK628430
      Consensus CDS
      CCDS23522.1
      UniProtKB/Swiss-Prot
      P11352
      Related
      ENSMUSP00000081010.5, OTTMUSP00000069174, ENSMUST00000082429.6, OTTMUST00000128632
      Conserved Domains (1) summary
      cd00340
      Location:13190
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      108339080..108340342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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