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    NPL3 mRNA-binding protein NPL3 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 852042, updated on 27-Mar-2017
    Gene symbol
    NPL3
    Gene description
    mRNA-binding protein NPL3
    Primary source
    SGD:S000002840
    Locus tag
    YDR432W
    Gene type
    protein coding
    RNA name
    mRNA-binding protein NPL3
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MTR13; MTS1; NAB1; NOP3
    See NPL3 in Map Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1328783..1330027)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene translation initiation factor eIF3 core subunit g Neighboring gene Cym1p Neighboring gene GPI-anchor transamidase GPI17 Neighboring gene leucine carboxy methyltransferase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II core binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    eukaryotic initiation factor 4G binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Names
    mRNA-binding protein NPL3
    NP_010720.3
    • RNA-binding protein; promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; represses translation initiation by binding eIF4G; required for pre-mRNA splicing; interacts with E3 ubiquitin ligase Bre1p, linking histone ubiquitination to mRNA processing; may have role in telomere maintenance; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in cytoplasm; protein abundance increases in response to DNA replication stress

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1328783..1330027
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180740.3NP_010720.3  TPA: mRNA-binding protein NPL3 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_010720.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q01560
      Conserved Domains (3) summary
      COG0724
      Location:5277
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12339
      Location:200272
      RRM2_SRSF1_4_like; RNA recognition motif 2 in serine/arginine-rich splicing factor SRSF1, SRSF4 and similar proteins
      cd12340
      Location:126192
      RBD_RRM1_NPL3; RNA recognition motif 1 in yeast nucleolar protein 3 (Npl3p) and similar proteins
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