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    Prox1 prospero homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 19130, updated on 8-Nov-2017
    Official Symbol
    Prox1provided by MGI
    Official Full Name
    prospero homeobox 1provided by MGI
    Primary source
    MGI:MGI:97772
    See related
    Ensembl:ENSMUSG00000010175 Vega:OTTMUSG00000040162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A230003G05Rik
    Orthologs
    Location:
    1 H6; 1 95.85 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (190118035..190170680, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (191945654..191994559, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39736 Neighboring gene predicted gene, 30446 Neighboring gene uncharacterized LOC102632463 Neighboring gene predicted gene, 39737 Neighboring gene predicted gene, 29678

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Ptf1a related regulatory pathway, organism-specific biosystem (from WikiPathways)
      Ptf1a related regulatory pathway, organism-specific biosystemBy summarizing published data together with our own results, this pathway shows a complicated relationships between transcriptional factors, miRNAs and some functional genes which are correlated toge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    acinar cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    aorta smooth muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    atrial cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in pancreas morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar granule cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic retina morphogenesis in camera-type eye IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    endocardium formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hepatocyte differentiation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hepatocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens fiber cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymph vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphangiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    lymphatic endothelial cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphatic endothelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    optic placode formation involved in camera-type eye formation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell cycle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of forebrain neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of heart growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of sarcomere organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription involved in lymphatic endothelial cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    skeletal muscle thin filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    venous blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular cardiac myofibril assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ventricular septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    prospero homeobox protein 1
    Names
    PROX-1
    homeobox prospero-like protein PROX1
    prospero-related homeobox 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008937.2NP_032963.1  prospero homeobox protein 1

      See identical proteins and their annotated locations for NP_032963.1

      Status: PROVISIONAL

      Source sequence(s)
      BC051411
      Consensus CDS
      CCDS35822.1
      UniProtKB/Swiss-Prot
      P48437
      Related
      ENSMUSP00000135703.1, OTTMUSP00000058419, ENSMUST00000175916.7, OTTMUST00000104400
      Conserved Domains (1) summary
      pfam05044
      Location:579730
      HPD; Homeo-prospero domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      190118035..190170680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497127.3XP_006497190.1  prospero homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497190.1

      Conserved Domains (1) summary
      pfam05044
      Location:579731
      HPD; Homeo-prospero domain
    2. XM_006497124.3XP_006497187.1  prospero homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497187.1

      Conserved Domains (1) summary
      pfam05044
      Location:579731
      HPD; Homeo-prospero domain
    3. XM_006497126.3XP_006497189.1  prospero homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497189.1

      Conserved Domains (1) summary
      pfam05044
      Location:579731
      HPD; Homeo-prospero domain
    4. XM_006497128.3XP_006497191.1  prospero homeobox protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006497191.1

      UniProtKB/Swiss-Prot
      P48437
      Related
      ENSMUSP00000010319.7, OTTMUSP00000058420, ENSMUST00000010319.13, OTTMUST00000104401
      Conserved Domains (1) summary
      pfam05044
      Location:579730
      HPD; Homeo-prospero domain
    5. XM_006497125.3XP_006497188.1  prospero homeobox protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006497188.1

      Conserved Domains (1) summary
      pfam05044
      Location:579731
      HPD; Homeo-prospero domain
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