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    Ephb1 Eph receptor B1 [ Mus musculus (house mouse) ]

    Gene ID: 270190, updated on 14-Nov-2017
    Official Symbol
    Ephb1provided by MGI
    Official Full Name
    Eph receptor B1provided by MGI
    Primary source
    MGI:MGI:1096337
    See related
    Ensembl:ENSMUSG00000032537 Vega:OTTMUSG00000021086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Elk; Net; Cek6; Elkh; Hek6; AW488255; 9330129L11; C130099E04Rik
    Orthologs
    Location:
    9; 9 F1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (101922128..102354693, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (101824458..102257023, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene 28979 Neighboring gene predicted pseudogene 5161 Neighboring gene predicted gene, 31326 Neighboring gene predicted gene, 31233 Neighboring gene microRNA 7243 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene kyphoscoliosis peptidase

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    axon guidance receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ephrin receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane-ephrin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transmembrane-ephrin receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cell chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    central nervous system projection neuron axonogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cranial nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic spine development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendritic spine morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of temperature stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ephrin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ephrin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immunological synapse formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of satellite cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of skeletal muscle satellite cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neural precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    optic nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    retinal ganglion cell axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal muscle satellite cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    filopodium tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ephrin type-B receptor 1
    NP_001161768.1
    NP_775623.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168296.1NP_001161768.1  ephrin type-B receptor 1 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks a coding exon compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AK036211, AK039530, BC057301, CT025594
      Consensus CDS
      CCDS52901.1
      UniProtKB/Swiss-Prot
      Q8CBF3
      UniProtKB/TrEMBL
      Q8CA63
      Related
      ENSMUSP00000082261.5, OTTMUSP00000023195, ENSMUST00000085169.11, OTTMUST00000049891
      Conserved Domains (7) summary
      cd05065
      Location:585841
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09551
      Location:867934
      SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
      smart00454
      Location:867932
      SAM; Sterile alpha motif
      cd10476
      Location:20195
      EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1
      cd00063
      Location:323429
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:435518
      fn3; Fibronectin type III domain
      pfam07714
      Location:585837
      Pkinase_Tyr; Protein tyrosine kinase
    2. NM_173447.3NP_775623.3  ephrin type-B receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_775623.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK036148, AK039530, BC057301
      Consensus CDS
      CCDS40742.1
      UniProtKB/Swiss-Prot
      Q8CBF3
      UniProtKB/TrEMBL
      Q8CA63
      Related
      ENSMUSP00000035129.7, OTTMUSP00000023194, ENSMUST00000035129.13, OTTMUST00000049888
      Conserved Domains (8) summary
      cd05065
      Location:614882
      PTKc_EphR_B; Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors
      cd09551
      Location:908975
      SAM_EPH-B1; SAM domain of EPH-B1 subfamily of tyrosine kinase receptors
      smart00454
      Location:908973
      SAM; Sterile alpha motif
      cd10476
      Location:20195
      EphR_LBD_B1; Ligand Binding Domain of Ephrin type-B Receptor 1
      cd00063
      Location:323429
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:435518
      fn3; Fibronectin type III domain
      pfam07714
      Location:619878
      Pkinase_Tyr; Protein tyrosine kinase
      pfam14575
      Location:546614
      EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      101922128..102354693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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