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    ANXA2 annexin A2 [ Homo sapiens (human) ]

    Gene ID: 302, updated on 13-Aug-2017
    Official Symbol
    ANXA2provided by HGNC
    Official Full Name
    annexin A2provided by HGNC
    Primary source
    HGNC:HGNC:537
    See related
    Ensembl:ENSG00000182718 MIM:151740; Vega:OTTHUMG00000132763
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P36; ANX2; LIP2; LPC2; CAL1H; LPC2D; ANX2L4; PAP-IV; HEL-S-270
    Summary
    This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    15q22.2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 15 NC_000015.10 (60347151..60398025, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (60639350..60690185, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370839 Neighboring gene uncharacterized LOC105370840 Neighboring gene ribosomal protein L36a pseudogene 44 Neighboring gene ribosomal protein S10 pseudogene 22 Neighboring gene interactor of little elongation complex ELL subunit 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies in african americans provides insights into the genetic architecture of type 2 diabetes.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
    Envelope transmembrane glycoprotein gp41 env Annexin II facilitates early steps in infection of macrophages following to the binding of HIV-1 gp120/gp41 to CD4 and CCR5 PubMed
    Nef nef HIV-1 Nef increases the production of exosomes and co-localizes with exosomal proteins CD63, AIP/Alix, AChE, Hsc70, LAMP2, and annexin A2 in HeLa cells PubMed
    Pr55(Gag) gag Annexin 2 (Anx2) interacts with HIV-1 Gag by coimmunoprecipitation in transfected cells and in a cell-free system; Anx2 co-localizes with Gag and CD63 in intracellular vesicles of HIV-1 infected macrophages PubMed
    gag Anx2 depletion by siRNA is associated with decreased infectivity of HIV-1 and aberrant HIV-1 Gag processing, indicating an interaction of Anx2 with Gag PubMed
    Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed

    Go to the HIV-1, Human Interaction Database

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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Rab GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    S100 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipase A2 inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to receptor activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    body fluid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    catabolism by host of symbiont protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    collagen fibril organization IEA
    Inferred from Electronic Annotation
    more info
     
    fibrinolysis IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-12-mediated signaling pathway TAS
    Traceable Author Statement
    more info
     
    membrane raft assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation by host of symbiont molecular function IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of development of symbiont involved in interaction with host IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of low-density lipoprotein particle receptor catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    osteoclast development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of fibroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of low-density lipoprotein particle clearance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of low-density lipoprotein particle receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of low-density lipoprotein receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor recycling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of vesicle fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to thyroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle budding from membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    PCSK9-AnxA2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Schmidt-Lanterman incisure IEA
    Inferred from Electronic Annotation
    more info
     
    azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    basement membrane IEA
    Inferred from Electronic Annotation
    more info
     
    basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell cortex IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    early endosome IEA
    Inferred from Electronic Annotation
    more info
     
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with extracellular matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    late endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    macropinosome IEA
    Inferred from Electronic Annotation
    more info
     
    melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myelin sheath adaxonal region IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IEA
    Inferred from Electronic Annotation
    more info
     
    sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    annexin A2
    Names
    annexin II
    annexin-2
    calpactin I heavy chain
    calpactin I heavy polypeptide
    calpactin-1 heavy chain
    chromobindin 8
    epididymis secretory protein Li 270
    lipocortin II
    placental anticoagulant protein IV
    protein I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002857.1NP_001002857.1  annexin A2 isoform 2

      See identical proteins and their annotated locations for NP_001002857.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AW087150, BC015834, BC023990
      Consensus CDS
      CCDS10175.1
      UniProtKB/Swiss-Prot
      P07355
      UniProtKB/TrEMBL
      A0A024R5Z7
      Related
      ENSP00000411352.2, OTTHUMP00000247477, ENST00000421017.6, OTTHUMT00000416474
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin; Annexin
    2. NM_001002858.2NP_001002858.1  annexin A2 isoform 1

      See identical proteins and their annotated locations for NP_001002858.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AA661718, AC087385, BC001388, BX640598
      Consensus CDS
      CCDS32256.1
      UniProtKB/Swiss-Prot
      P07355
      Related
      ENSP00000346032.3, OTTHUMP00000247475, ENST00000332680.8, OTTHUMT00000416470
      Conserved Domains (1) summary
      pfam00191
      Location:127192
      Annexin; Annexin
    3. NM_001136015.2NP_001129487.1  annexin A2 isoform 2

      See identical proteins and their annotated locations for NP_001129487.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' UTR, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AA661718, BC093056
      Consensus CDS
      CCDS10175.1
      UniProtKB/Swiss-Prot
      P07355
      UniProtKB/TrEMBL
      A0A024R5Z7
      Related
      ENSP00000379342.3, OTTHUMP00000163650, ENST00000396024.7, OTTHUMT00000256135
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin; Annexin
    4. NM_004039.2NP_004030.1  annexin A2 isoform 2

      See identical proteins and their annotated locations for NP_004030.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a segment in the 5' region, as compared to variant 1. It uses a downstream AUG start codon and encodes isoform 2 which has a shorter N-terminus, as compared to isoform 1. Variants 2, 3 and 4 encode the same isoform (2).
      Source sequence(s)
      AW087150, BC015834, D00017
      Consensus CDS
      CCDS10175.1
      UniProtKB/Swiss-Prot
      P07355
      UniProtKB/TrEMBL
      A0A024R5Z7
      Related
      ENSP00000387545.2, OTTHUMP00000247474, ENST00000451270.6, OTTHUMT00000416469
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin; Annexin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p7 Primary Assembly

      Range
      60347151..60398025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017022092.1XP_016877581.1  annexin A2 isoform X2

      Conserved Domains (1) summary
      pfam00191
      Location:152217
      Annexin; Annexin
    2. XM_017022093.1XP_016877582.1  annexin A2 isoform X2

      Conserved Domains (1) summary
      pfam00191
      Location:152217
      Annexin; Annexin
    3. XM_017022091.1XP_016877580.1  annexin A2 isoform X1

      UniProtKB/Swiss-Prot
      P07355
      UniProtKB/TrEMBL
      A0A024R5Z7
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin; Annexin
    4. XM_017022090.1XP_016877579.1  annexin A2 isoform X1

      UniProtKB/Swiss-Prot
      P07355
      UniProtKB/TrEMBL
      A0A024R5Z7
      Conserved Domains (1) summary
      pfam00191
      Location:109174
      Annexin; Annexin
    5. XM_011521477.2XP_011519779.1  annexin A2 isoform X2

      Conserved Domains (1) summary
      pfam00191
      Location:152217
      Annexin; Annexin

    Alternate CHM1_1.1

    Genomic

    1. NC_018926.2 Alternate CHM1_1.1

      Range
      60757784..60809419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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