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    Adra2a adrenoceptor alpha 2A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25083, updated on 22-Apr-2017
    Official Symbol
    Adra2aprovided by RGD
    Official Full Name
    adrenoceptor alpha 2Aprovided by RGD
    Primary source
    RGD:2056
    See related
    Ensembl:ENSRNOG00000047545
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RG20; CA2-47; RATRG20
    Orthologs
    Location:
    1q55
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (274766283..274769083)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (282178475..282181275)

    Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene BBSome interacting protein 1 Neighboring gene SHOC2 leucine-rich repeat scaffold protein Neighboring gene uncharacterized LOC102552097 Neighboring gene uncharacterized LOC102553657

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-2C adrenergic receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    alpha-2C adrenergic receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha2-adrenergic receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    alpha2-adrenergic receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    alpha2-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    epinephrine binding IEA
    Inferred from Electronic Annotation
    more info
     
    epinephrine binding ISO
    Inferred from Sequence Orthology
    more info
     
    heterotrimeric G-protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    heterotrimeric G-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    norepinephrine binding IEA
    Inferred from Electronic Annotation
    more info
     
    norepinephrine binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    thioesterase binding IEA
    Inferred from Electronic Annotation
    more info
     
    thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity by adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    activation of MAPK activity by adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase B activity IEA
    Inferred from Electronic Annotation
    more info
     
    activation of protein kinase B activity ISO
    Inferred from Sequence Orthology
    more info
     
    activation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acute inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adenylate cyclase-activating adrenergic receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    adenylate cyclase-inhibiting adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    adenylate cyclase-inhibiting adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hormone stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    fear response ISO
    Inferred from Sequence Orthology
    more info
     
    female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of lipid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of uterine smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phospholipase C-activating adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase C-activating adrenergic receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    platelet activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of blood vessel diameter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of epidermal growth factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of membrane protein ectodomain proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    thermoception IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    alpha-2A adrenergic receptor
    Names
    adrenergic receptor, alpha 2a
    adrenergic, alpha-2A-, receptor
    alpha-2A adrenoceptor
    alpha-2A adrenoreceptor
    alpha-2AAR
    alpha-2D adrenergic receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012739.3NP_036871.3  alpha-2A adrenergic receptor

      See identical proteins and their annotated locations for NP_036871.3

      Status: VALIDATED

      Source sequence(s)
      AW915790, AW919837, CB584098, CB763650, CO574013, U49747, U79031
      UniProtKB/Swiss-Prot
      P22909
      UniProtKB/TrEMBL
      M0R9R3
      Related
      ENSRNOP00000066242.1, ENSRNOT00000071541.1
      Conserved Domains (2) summary
      pfam00001
      Location:65441
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:57185
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

      Range
      274766283..274769083
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000069.1 Alternate Rn_Celera

      Range
      248775483..248778283
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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