Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    PDR5 ATP-binding cassette multidrug transporter PDR5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854324, updated on 8-Apr-2018
    Gene symbol
    PDR5
    Gene description
    ATP-binding cassette multidrug transporter PDR5
    Primary source
    SGD:S000005679
    Locus tag
    YOR153W
    Gene type
    protein coding
    RNA name
    ATP-binding cassette multidrug transporter PDR5
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LEM1; STS1; YDR1
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (619840..624375)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II core subunit RPB2 Neighboring gene Atg40p Neighboring gene Slp1p Neighboring gene IMP 5'-nucleotidase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • ABC transporters, organism-specific biosystem (from KEGG)
      ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC transporters, conserved biosystem (from KEGG)
      ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ATPase activity, coupled to transmembrane movement of substances IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic transmembrane transporting ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    xenobiotic transmembrane transporting ATPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular cation homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to drug IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    drug export IEA
    Inferred from Electronic Annotation
    more info
     
    drug transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    drug transport TAS
    Traceable Author Statement
    more info
    PubMed 
    response to antibiotic IEA
    Inferred from Electronic Annotation
    more info
     
    response to cycloheximide IEA
    Inferred from Electronic Annotation
    more info
     
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell periphery HDA PubMed 
    integral component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion HDA PubMed 
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    ATP-binding cassette multidrug transporter PDR5
    NP_014796.3
    • Plasma membrane ATP-binding cassette (ABC) transporter; multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth; PDR5 has a paralog, PDR15, that arose from the whole genome duplication

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      619840..624375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183572.3NP_014796.3  TPA: ATP-binding cassette multidrug transporter PDR5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014796.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P33302
      Conserved Domains (6) summary
      cd03232
      Location:8681094
      ABCG_PDR_domain2; Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters
      cd03233
      Location:164392
      ABCG_PDR_domain1; First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters
      TIGR00956
      Location:1001503
      3a01205; Pleiotropic Drug Resistance (PDR) Family protein
      pfam01061
      Location:11941402
      ABC2_membrane; ABC-2 type transporter
      pfam06422
      Location:725819
      PDR_CDR; CDR ABC transporter
      pfam14510
      Location:68155
      ABC_trans_N; ABC-transporter extracellular N-terminal
    Support Center