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    Scn4a sodium voltage-gated channel alpha subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25722, updated on 4-Feb-2018
    Official Symbol
    Scn4aprovided by RGD
    Official Full Name
    sodium voltage-gated channel alpha subunit 4provided by RGD
    Primary source
    RGD:3636
    See related
    Ensembl:ENSRNOG00000012134
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NCHVS; Nav1.4; microI
    Summary
    voltage-gated Na+ channel subunit [RGD, Feb 2006]
    Expression
    Restricted expression toward (RPKM 389.5) See more
    Orthologs
    Location:
    10q32.1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94505026..94557803, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (94256140..94305964, complement)

    Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene growth hormone 1 Neighboring gene CD79b molecule Neighboring gene uncharacterized LOC108352146 Neighboring gene proline rich 29 Neighboring gene intercellular adhesion molecule 2 Neighboring gene endoplasmic reticulum to nucleus signaling 1 Neighboring gene 40S ribosomal protein S10 pseudogene

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    voltage-gated ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    voltage-gated sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    voltage-gated sodium channel activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    voltage-gated sodium channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cation transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    choline transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane depolarization during action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    neuronal action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sodium ion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    voltage-gated sodium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    sodium channel protein type 4 subunit alpha
    Names
    Sodium channel voltage-gated type IV alpha polypeptide
    mu-1
    skM1
    sodium channel protein skeletal muscle subunit alpha
    sodium channel protein type IV subunit alpha
    sodium channel, voltage-gated, type 4, alpha polypeptide
    sodium channel, voltage-gated, type 4, alpha subunit
    sodium channel, voltage-gated, type IV, alpha polypeptide
    sodium channel, voltage-gated, type IV, alpha subunit
    voltage-gated sodium channel subunit alpha Nav1.4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013178.1NP_037310.1  sodium channel protein type 4 subunit alpha

      See identical proteins and their annotated locations for NP_037310.1

      Status: PROVISIONAL

      Source sequence(s)
      M26643
      UniProtKB/Swiss-Prot
      P15390
      Related
      ENSRNOP00000016841.4, ENSRNOT00000016841.4
      Conserved Domains (5) summary
      cd13433
      Location:12891341
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:10411297
      Ion_trans; Ion transport protein
      pfam06512
      Location:8101019
      Na_trans_assoc; Sodium ion transport-associated
      pfam16905
      Location:16131668
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl21478
      Location:419491
      ATP-synt_B; ATP synthase B/B' CF(0)

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

      Range
      94505026..94557803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017597046.1XP_017452535.1  sodium channel protein type 4 subunit alpha isoform X1

      UniProtKB/TrEMBL
      D3ZW75
      Conserved Domains (5) summary
      cd13433
      Location:12891341
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:10411297
      Ion_trans; Ion transport protein
      pfam06512
      Location:8101019
      Na_trans_assoc; Sodium ion transport-associated
      pfam16905
      Location:16131668
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl21478
      Location:419491
      ATP-synt_B; ATP synthase B/B' CF(0)
    2. XM_006247559.3XP_006247621.1  sodium channel protein type 4 subunit alpha isoform X1

      UniProtKB/TrEMBL
      D3ZW75
      Conserved Domains (5) summary
      cd13433
      Location:12891341
      Na_channel_gate; Inactivation gate of the voltage-gated sodium channel alpha subunits
      pfam00520
      Location:10411297
      Ion_trans; Ion transport protein
      pfam06512
      Location:8101019
      Na_trans_assoc; Sodium ion transport-associated
      pfam16905
      Location:16131668
      GPHH; Voltage-dependent L-type calcium channel, IQ-associated
      cl21478
      Location:419491
      ATP-synt_B; ATP synthase B/B' CF(0)

    Alternate Rn_Celera

    Genomic

    1. AC_000078.1 Alternate Rn_Celera

      Range
      89922418..89970101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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