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    Mib1 mindbomb E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 225164, updated on 8-May-2017
    Official Symbol
    Mib1provided by MGI
    Official Full Name
    mindbomb E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:2443157
    See related
    Ensembl:ENSMUSG00000024294 Vega:OTTMUSG00000028579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mib; DIP-1; mKIAA1323; E430019M12Rik
    Orthologs
    Location:
    18; 18 A1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (10725553..10818578)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (10725623..10812215)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 3 Neighboring gene RIKEN cDNA 4930563E18 gene Neighboring gene Mir133a-1, Mir1b and Mir1a-2 host gene Neighboring gene microRNA 133a-1 Neighboring gene microRNA 1a-2 Neighboring gene microRNA 1b Neighboring gene apurinic/apyrimidinic endonuclease 1 pseudogene Neighboring gene predicted gene, 35814 Neighboring gene PHD finger protein 14 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC18948

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    somitogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase MIB1
    Names
    DAPK-interacting protein-1
    RING-type E3 ubiquitin transferase MIB1
    mind bomb homolog 1
    mind bomb-1
    mindbomb homolog 1
    skeletrophin
    NP_659109.2
    XP_006525873.1
    XP_006525874.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144860.2NP_659109.2  E3 ubiquitin-protein ligase MIB1

      See identical proteins and their annotated locations for NP_659109.2

      Status: PROVISIONAL

      Source sequence(s)
      AY245539
      Consensus CDS
      CCDS29058.1
      UniProtKB/Swiss-Prot
      Q80SY4
      Related
      ENSMUSP00000054428.4, OTTMUSP00000036148, ENSMUST00000052838.10, OTTMUST00000070815
      Conserved Domains (9) summary
      COG0666
      Location:494756
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:524652
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:406494
      Ank_2; Ankyrin repeats (3 copies)
      pfam13920
      Location:862907
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cl02529
      Location:435484
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl19548
      Location:301453
      DUF515; Protein of unknown function (DUF515)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      10725553..10818578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525810.2XP_006525873.1  E3 ubiquitin-protein ligase MIB1 isoform X1

      See identical proteins and their annotated locations for XP_006525873.1

      UniProtKB/Swiss-Prot
      Q80SY4
      Conserved Domains (9) summary
      COG0666
      Location:494756
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:524652
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:406494
      Ank_2; Ankyrin repeats (3 copies)
      pfam13920
      Location:862907
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cl02529
      Location:435484
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl19548
      Location:301453
      DUF515; Protein of unknown function (DUF515)
    2. XM_006525811.3XP_006525874.1  E3 ubiquitin-protein ligase MIB1 isoform X1

      See identical proteins and their annotated locations for XP_006525874.1

      UniProtKB/Swiss-Prot
      Q80SY4
      Conserved Domains (9) summary
      COG0666
      Location:494756
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      cd00204
      Location:524652
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd02339
      Location:83127
      ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
      pfam06701
      Location:154218
      MIB_HERC2; Mib_herc2
      pfam12796
      Location:406494
      Ank_2; Ankyrin repeats (3 copies)
      pfam13920
      Location:862907
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      sd00045
      Location:562593
      ANK; ANK repeat [structural motif]
      cl02529
      Location:435484
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl19548
      Location:301453
      DUF515; Protein of unknown function (DUF515)
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