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    POL32 DNA polymerase delta subunit POL32 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 853500, updated on 15-Nov-2016
    Gene symbol
    POL32
    Gene description
    DNA polymerase delta subunit POL32
    Primary source
    SGD:S000003804
    Locus tag
    YJR043C
    Gene type
    protein coding
    RNA name
    DNA polymerase delta subunit POL32
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    REV5
    See POL32 in Map Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (516461..517513, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Urb2p Neighboring gene Nup85p Neighboring gene tRNA Neighboring gene Vps55p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Base excision repair, organism-specific biosystem (from KEGG)
      Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • Base excision repair, conserved biosystem (from KEGG)
      Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
    • DNA replication, organism-specific biosystem (from KEGG)
      DNA replication, organism-specific biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
    • DNA replication, conserved biosystem (from KEGG)
      DNA replication, conserved biosystemA complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (D...
    • Homologous recombination, organism-specific biosystem (from KEGG)
      Homologous recombination, organism-specific biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Homologous recombination, conserved biosystem (from KEGG)
      Homologous recombination, conserved biosystemHomologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves...
    • Metabolic pathways, organism-specific biosystem (from KEGG)
      Metabolic pathways, organism-specific biosystem
      Metabolic pathways
    • Mismatch repair, organism-specific biosystem (from KEGG)
      Mismatch repair, organism-specific biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Mismatch repair, conserved biosystem (from KEGG)
      Mismatch repair, conserved biosystemDNA mismatch repair (MMR) is a highly conserved biological pathway that plays a key role in maintaining genomic stability. MMR corrects DNA mismatches generated during DNA replication, thereby preven...
    • Nucleotide excision repair, organism-specific biosystem (from KEGG)
      Nucleotide excision repair, organism-specific biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
    • Nucleotide excision repair, conserved biosystem (from KEGG)
      Nucleotide excision repair, conserved biosystemNucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the ...
    • Purine metabolism, organism-specific biosystem (from KEGG)
      Purine metabolism, organism-specific biosystem
      Purine metabolism
    • Purine metabolism, conserved biosystem (from KEGG)
      Purine metabolism, conserved biosystem
      Purine metabolism
    • Pyrimidine metabolism, organism-specific biosystem (from KEGG)
      Pyrimidine metabolism, organism-specific biosystem
      Pyrimidine metabolism
    • Pyrimidine metabolism, conserved biosystem (from KEGG)
      Pyrimidine metabolism, conserved biosystem
      Pyrimidine metabolism
    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA-directed DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to DNA-directed DNA polymerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to single-stranded DNA 3'-5' exodeoxyribonuclease activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA amplification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    DNA replication, removal of RNA primer IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA-dependent DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    base-excision repair TAS
    Traceable Author Statement
    more info
    PubMed 
    double-strand break repair via break-induced replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lagging strand elongation TAS
    Traceable Author Statement
    more info
    PubMed 
    leading strand elongation TAS
    Traceable Author Statement
    more info
    PubMed 
    mismatch repair NAS
    Non-traceable Author Statement
    more info
    PubMed 
    nucleic acid phosphodiester bond hydrolysis IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair TAS
    Traceable Author Statement
    more info
    PubMed 
    postreplication repair TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    delta DNA polymerase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    DNA polymerase delta subunit POL32
    NP_012577.1
    • Third subunit of DNA polymerase delta; involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; forms a complex with Rev3p, Rev7p and Pol31p; interacts with Hys2p, PCNA (Pol30p), and Pol1p

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      516461..517513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181701.1NP_012577.1  TPA: DNA polymerase delta subunit POL32 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_012577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47110
      Conserved Domains (1) summary
      pfam09507
      Location:125348
      CDC27; DNA polymerase subunit Cdc27
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