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    OGFR opioid growth factor receptor [ Homo sapiens (human) ]

    Gene ID: 11054, updated on 22-Apr-2017
    Official Symbol
    OGFRprovided by HGNC
    Official Full Name
    opioid growth factor receptorprovided by HGNC
    Primary source
    HGNC:HGNC:15768
    See related
    Ensembl:ENSG00000060491 MIM:606459; Vega:OTTHUMG00000032937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    20q13.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 20 NC_000020.11 (62804825..62814000)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61436156..61445352)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372716 Neighboring gene MRG domain binding protein Neighboring gene OGFR antisense RNA 1 Neighboring gene collagen type IX alpha 3 chain Neighboring gene transcription factor like 5 Neighboring gene diphthamide biosynthesis 3 pseudogene 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    opioid receptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    opioid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell growth NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    opioid growth factor receptor
    Names
    protein 7-60
    zeta-type opioid receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033957.1 RefSeqGene

      Range
      4976..14176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007346.3NP_031372.2  opioid growth factor receptor

      See identical proteins and their annotated locations for NP_031372.2

      Status: REVIEWED

      Source sequence(s)
      AF172453, AL035669
      Consensus CDS
      CCDS13504.1
      UniProtKB/Swiss-Prot
      Q9NZT2
      Related
      ENSP00000290291.6, OTTHUMP00000031503, ENST00000290291.10, OTTHUMT00000080067
      Conserved Domains (2) summary
      pfam04664
      Location:86293
      OGFr_N; Opioid growth factor receptor (OGFr) conserved region
      pfam15250
      Location:537649
      Raftlin; Raftlin

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p7 Primary Assembly

      Range
      62804825..62814000
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018931.2 Alternate CHM1_1.1

      Range
      61337230..61346422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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