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    ABCC1 ATP binding cassette subfamily C member 1 [ Homo sapiens (human) ]

    Gene ID: 4363, updated on 20-Feb-2017
    Official Symbol
    ABCC1provided by HGNC
    Official Full Name
    ATP binding cassette subfamily C member 1provided by HGNC
    Primary source
    HGNC:HGNC:51
    See related
    Ensembl:ENSG00000103222 MIM:158343; Vega:OTTHUMG00000048267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRP; ABCC; GS-X; MRP1; ABC29
    Summary
    The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
    Orthologs
    Location:
    16p13.11
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 16 NC_000016.10 (15949577..16143074)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (16043434..16236931)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 213, pseudogene Neighboring gene uncharacterized LOC107984869 Neighboring gene FGFR1OP N-terminal like Neighboring gene ribosomal protein L15 pseudogene 20 Neighboring gene ribosomal protein L17 pseudogene 40 Neighboring gene ATP binding cassette subfamily C member 6 Neighboring gene uncharacterized LOC105371100 Neighboring gene NODAL modulator 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env NF-kappaB and JNK signaling are involved in gp120-induced multidrug resistance protein 1 (Mrp1) regulation during an HIV-1 associated inflammatory response PubMed
    Tat tat HIV-1 Tat upregulates expression of MRP1 through activation of the mitogen-activated protein kinase signaling cascade PubMed
    tat HIV-1 Tat specifically upregulates MRP1 messenger ribonucleic acid and protein expression both in brain micro vascular endothelial cells (BMEC) and astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    • ABC transporters, organism-specific biosystem (from KEGG)
      ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC transporters, conserved biosystem (from KEGG)
      ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
    • ABC-family proteins mediated transport, organism-specific biosystem (from REACTOME)
      ABC-family proteins mediated transport, organism-specific biosystemThe ATP-binding cassette (ABC) superfamily of active transporters involves a large number of functionally diverse transmembrane proteins. They transport a variety of compounds through membranes agai...
    • Antifolate resistance, organism-specific biosystem (from KEGG)
      Antifolate resistance, organism-specific biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
    • Antifolate resistance, conserved biosystem (from KEGG)
      Antifolate resistance, conserved biosystemSince the 1940s, antifolates have played a pivotal role in drug treatment of malignant, microbial, parasitic and chronic inflammatory diseases. The molecular basis of the anti-proliferative activity ...
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystem (from REACTOME)
      Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystemVitamin B12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating wi...
    • Irinotecan Pathway, organism-specific biosystem (from WikiPathways)
      Irinotecan Pathway, organism-specific biosystemThis pathway shows the biotransformation of the chemotherapy prodrug irinotecan to form the active metabolite SN-38, an inhibitor of DNA topoisomerase I. SN-38 is primarily metabolized to the inactiv...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
      Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
    • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
      Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • S1P1 pathway, organism-specific biosystem (from Pathway Interaction Database)
      S1P1 pathway, organism-specific biosystem
      S1P1 pathway
    • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
      Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
      Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
    • Sphingosine 1-phosphate (S1P) pathway, organism-specific biosystem (from Pathway Interaction Database)
      Sphingosine 1-phosphate (S1P) pathway, organism-specific biosystem
      Sphingosine 1-phosphate (S1P) pathway
    • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
      Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Vitamin digestion and absorption, organism-specific biosystem (from KEGG)
      Vitamin digestion and absorption, organism-specific biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    • Vitamin digestion and absorption, conserved biosystem (from KEGG)
      Vitamin digestion and absorption, conserved biosystemVitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactio...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • DKFZp781G125, DKFZp686N04233

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ATPase activity, coupled to transmembrane movement of substances TAS
    Traceable Author Statement
    more info
     
    ATPase-coupled anion transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    cobalamin-transporting ATPase activity TAS
    Traceable Author Statement
    more info
     
    glutathione S-conjugate-exporting ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glutathione transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    xenobiotic-transporting ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    ATP hydrolysis coupled anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    cobalamin metabolic process TAS
    Traceable Author Statement
    more info
     
    cobalamin transport IEA
    Inferred from Electronic Annotation
    more info
     
    drug transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    glutathione transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    leukotriene metabolic process TAS
    Traceable Author Statement
    more info
     
    response to drug TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane transport TAS
    Traceable Author Statement
    more info
     
    transport TAS
    Traceable Author Statement
    more info
    PubMed 
    vitamin transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    multidrug resistance-associated protein 1
    Names
    ATP-binding cassette transporter variant ABCC1delta-ex13
    ATP-binding cassette transporter variant ABCC1delta-ex13&14
    ATP-binding cassette transporter variant ABCC1delta-ex25
    ATP-binding cassette transporter variant ABCC1delta-ex25&26
    ATP-binding cassette, sub-family C (CFTR/MRP), member 1
    LTC4 transporter
    leukotriene C(4) transporter

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028268.1 RefSeqGene

      Range
      5001..198498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004996.3NP_004987.2  multidrug resistance-associated protein 1

      See identical proteins and their annotated locations for NP_004987.2

      Status: REVIEWED

      Source sequence(s)
      AC025778, AC130651, AC136624, X78338
      Consensus CDS
      CCDS42122.1
      UniProtKB/Swiss-Prot
      P33527
      Related
      ENSP00000382342, OTTHUMP00000045904, ENST00000399410, OTTHUMT00000109701
      Conserved Domains (4) summary
      TIGR00957
      Location:71530
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:12911511
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:644845
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:9791244
      ABC_membrane; ABC transporter transmembrane region

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p7 Primary Assembly

      Range
      15949577..16143074
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017023237.1XP_016878726.1  multidrug resistance-associated protein 1 isoform X1

    2. XM_017023240.1XP_016878729.1  multidrug resistance-associated protein 1 isoform X6

    3. XM_017023242.1XP_016878731.1  multidrug resistance-associated protein 1 isoform X8

    4. XM_011522498.2XP_011520800.1  multidrug resistance-associated protein 1 isoform X5

      Conserved Domains (4) summary
      TIGR00957
      Location:261499
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:12601480
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:613814
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:9481213
      ABC_membrane; ABC transporter transmembrane region
    5. XM_017023238.1XP_016878727.1  multidrug resistance-associated protein 1 isoform X3

    6. XM_017023239.1XP_016878728.1  multidrug resistance-associated protein 1 isoform X4

    7. XM_017023241.1XP_016878730.1  multidrug resistance-associated protein 1 isoform X7

      Related
      ENSP00000382340, ENST00000399408
    8. XM_017023243.1XP_016878732.1  multidrug resistance-associated protein 1 isoform X9

    9. XM_011522497.1XP_011520799.1  multidrug resistance-associated protein 1 isoform X2

      Related
      ENSP00000461615, OTTHUMP00000256414, ENST00000572882, OTTHUMT00000436390
      Conserved Domains (4) summary
      TIGR00957
      Location:91522
      MRP_assoc_pro; multi drug resistance-associated protein (MRP)
      cd03244
      Location:12831503
      ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
      cd03250
      Location:636837
      ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
      pfam00664
      Location:9711236
      ABC_membrane; ABC transporter transmembrane region

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187607.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      1665690..1800966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018927.2 Alternate CHM1_1.1

      Range
      16185916..16321192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_019862.2: Suppressed sequence

      Description
      NM_019862.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
    2. NM_019898.2: Suppressed sequence

      Description
      NM_019898.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
    3. NM_019899.2: Suppressed sequence

      Description
      NM_019899.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
    4. NM_019900.2: Suppressed sequence

      Description
      NM_019900.2: This RefSeq was permanently suppressed because currently there is no full-length support for the transcript and the protein.
    5. NM_019901.1: Suppressed sequence

      Description
      NM_019901.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    6. NM_019902.1: Suppressed sequence

      Description
      NM_019902.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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